Successful and reproducible myocardial opacification during two-dimensional echocardiography from right heart injection of contrast

Flordeliza S. Villanueva, William P. Glasheen, Jiri Sklenar, Ananda R. Jayaweera, Sanjiv Kaul

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

Background. Myocardial contrast echocardiography currently involves intra-arterial injection of contrast. For this technique to have a broader application, it is necessary that myocardial opacification be achieved from a venous injection of contrast. Methods and Results. To achieve myocardial opacification after right-side injection of contrast, two groups of open-chest anesthetized dogs were studied. Group 1 included nine dogs in whom microbubbles of various sizes, concentrations, and volumes were injected into the left atrium to determine microbubble characteristics that influence myocardial opacification. Group 2 included eight dogs in whom the effect of the combination of microbubble characteristics and myocardial blood flow on myocardial opacification was evaluated after right atrial injection of contrast. Background-subtracted time-intensity plots were generated from the myocardium to measure peak videointensity. In the group 2 dogs, digital subtraction and color coding were used to further highlight the contrast effect. The number, concentration, and size of the microbubbles all independently affected (p2=9.01, p=0.003). No changes were noted in left atrial, left ventricular, and pulmonary artery pressures despite injection of large numbers of microbubbles into the right atrium. Conclusions. Successful and reproducible myocardial opacification can be achieved during myocardial contrast echocardiography after right atrial injection of contrast. These findings could have far-reaching implications in the use of myocardial contrast echocardiography in acute and chronic ischemic syndromes in humans.

Original languageEnglish (US)
Pages (from-to)1557-1564
Number of pages8
JournalCirculation
Volume85
Issue number4
StatePublished - Apr 1992
Externally publishedYes

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Microbubbles
Echocardiography
Injections
Dogs
Heart Atria
Intra-Arterial Injections
Pulmonary Artery
Myocardium
Thorax
Color
Pressure

Keywords

  • Echocardiography
  • Microbubbles
  • Myocardial opacification

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Successful and reproducible myocardial opacification during two-dimensional echocardiography from right heart injection of contrast. / Villanueva, Flordeliza S.; Glasheen, William P.; Sklenar, Jiri; Jayaweera, Ananda R.; Kaul, Sanjiv.

In: Circulation, Vol. 85, No. 4, 04.1992, p. 1557-1564.

Research output: Contribution to journalArticle

Villanueva, Flordeliza S. ; Glasheen, William P. ; Sklenar, Jiri ; Jayaweera, Ananda R. ; Kaul, Sanjiv. / Successful and reproducible myocardial opacification during two-dimensional echocardiography from right heart injection of contrast. In: Circulation. 1992 ; Vol. 85, No. 4. pp. 1557-1564.
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N2 - Background. Myocardial contrast echocardiography currently involves intra-arterial injection of contrast. For this technique to have a broader application, it is necessary that myocardial opacification be achieved from a venous injection of contrast. Methods and Results. To achieve myocardial opacification after right-side injection of contrast, two groups of open-chest anesthetized dogs were studied. Group 1 included nine dogs in whom microbubbles of various sizes, concentrations, and volumes were injected into the left atrium to determine microbubble characteristics that influence myocardial opacification. Group 2 included eight dogs in whom the effect of the combination of microbubble characteristics and myocardial blood flow on myocardial opacification was evaluated after right atrial injection of contrast. Background-subtracted time-intensity plots were generated from the myocardium to measure peak videointensity. In the group 2 dogs, digital subtraction and color coding were used to further highlight the contrast effect. The number, concentration, and size of the microbubbles all independently affected (p2=9.01, p=0.003). No changes were noted in left atrial, left ventricular, and pulmonary artery pressures despite injection of large numbers of microbubbles into the right atrium. Conclusions. Successful and reproducible myocardial opacification can be achieved during myocardial contrast echocardiography after right atrial injection of contrast. These findings could have far-reaching implications in the use of myocardial contrast echocardiography in acute and chronic ischemic syndromes in humans.

AB - Background. Myocardial contrast echocardiography currently involves intra-arterial injection of contrast. For this technique to have a broader application, it is necessary that myocardial opacification be achieved from a venous injection of contrast. Methods and Results. To achieve myocardial opacification after right-side injection of contrast, two groups of open-chest anesthetized dogs were studied. Group 1 included nine dogs in whom microbubbles of various sizes, concentrations, and volumes were injected into the left atrium to determine microbubble characteristics that influence myocardial opacification. Group 2 included eight dogs in whom the effect of the combination of microbubble characteristics and myocardial blood flow on myocardial opacification was evaluated after right atrial injection of contrast. Background-subtracted time-intensity plots were generated from the myocardium to measure peak videointensity. In the group 2 dogs, digital subtraction and color coding were used to further highlight the contrast effect. The number, concentration, and size of the microbubbles all independently affected (p2=9.01, p=0.003). No changes were noted in left atrial, left ventricular, and pulmonary artery pressures despite injection of large numbers of microbubbles into the right atrium. Conclusions. Successful and reproducible myocardial opacification can be achieved during myocardial contrast echocardiography after right atrial injection of contrast. These findings could have far-reaching implications in the use of myocardial contrast echocardiography in acute and chronic ischemic syndromes in humans.

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