TY - JOUR
T1 - Substance P in human cerebrospinal fluid
T2 - Reductions in peripheral neuropathy and autonomic dysfunction
AU - Nutt, John G.
AU - Mroz, Edmund A.
AU - Leeman, Susan E.
AU - Williams, Adrian C.
AU - Engel, W. King
AU - Chase, Thomas N.
PY - 1980/12
Y1 - 1980/12
N2 - Substance P (SP), a putative peptide neurotransmitter, was measured in human lumbar cerebrospinal fluid (CSF) by radioimmunoassay. Substance P-like immunoreactivity (SPLI) was present in the CSF of 18 neurologically normal adults in concentrations ranging from 2.9 to 11.1 fmol per milliliter, with a mean of 7.0 ± 0.6 fmol per milliliter (mean ± SE). Slightly more than half of the CSF-SPLI cochromatographed with synthetic SP on Sephadex G-25. There was no apparent gradient in CSF-SPLI concentration over the first 30 ml of CSF removed by lumbar puncture. Mean concentrations of CSF-SPLI in patients with Huntington disease, parkinsonism, miscellaneous dyskinesias, progressive supranuclear palsy, myopathy, and amyotrophic lateral sclerosis did not differ significantly from normal. Patients with neuropathy or multiple-system atrophy (Shy-Drager syndrome) had significantly reduced mean CSF-SPLI concentrations. These observations suggest that lumbar CSF-SPLI arises largely from spinal cord, nerve roots, or dorsal root ganglia, and that pathologic processes affecting these structures may be reflected by reduced levels of CSF-SPLI.
AB - Substance P (SP), a putative peptide neurotransmitter, was measured in human lumbar cerebrospinal fluid (CSF) by radioimmunoassay. Substance P-like immunoreactivity (SPLI) was present in the CSF of 18 neurologically normal adults in concentrations ranging from 2.9 to 11.1 fmol per milliliter, with a mean of 7.0 ± 0.6 fmol per milliliter (mean ± SE). Slightly more than half of the CSF-SPLI cochromatographed with synthetic SP on Sephadex G-25. There was no apparent gradient in CSF-SPLI concentration over the first 30 ml of CSF removed by lumbar puncture. Mean concentrations of CSF-SPLI in patients with Huntington disease, parkinsonism, miscellaneous dyskinesias, progressive supranuclear palsy, myopathy, and amyotrophic lateral sclerosis did not differ significantly from normal. Patients with neuropathy or multiple-system atrophy (Shy-Drager syndrome) had significantly reduced mean CSF-SPLI concentrations. These observations suggest that lumbar CSF-SPLI arises largely from spinal cord, nerve roots, or dorsal root ganglia, and that pathologic processes affecting these structures may be reflected by reduced levels of CSF-SPLI.
UR - http://www.scopus.com/inward/record.url?scp=0019209244&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019209244&partnerID=8YFLogxK
U2 - 10.1212/wnl.30.12.1280
DO - 10.1212/wnl.30.12.1280
M3 - Article
C2 - 6161319
AN - SCOPUS:0019209244
SN - 0028-3878
VL - 30
SP - 1280
EP - 1285
JO - Neurology
JF - Neurology
IS - 12
ER -