TY - JOUR
T1 - Subcortical grey matter volumes predict subsequent walking function in early multiple sclerosis
AU - Nourbakhsh, Bardia
AU - Azevedo, Christina
AU - Maghzi, Amir Hadi
AU - Spain, Rebecca
AU - Pelletier, Daniel
AU - Waubant, Emmanuelle
N1 - Publisher Copyright:
© 2016 Elsevier B.V.
PY - 2016/7/15
Y1 - 2016/7/15
N2 - Background Atrophy of subcortical grey matter structures has been reported to be associated with clinical measures of disability in multiple sclerosis (MS) patients. It is not clear if the degree of tissue loss in patients with very early MS is associated with changes in disability measures. Objective To study the association between subcortical grey matter structure volumes and clinical disability outcomes. Methods Relapsing MS patients within 12 months of clinical onset were enrolled in a neuroprotection trial of riluzole versus placebo with up to 36 months of follow-up and serial brain MRI and clinical assessments. MRI metrics, including thalamic, putamen, caudate, pallidum and cerebellar cortical volume, were measured by an automated, custom-made FreeSurfer pipeline. Volumes were normalized for head size. Clinical measures included EDSS, MSFC scores and its components. Mixed model regression measured time trends and associations between imaging and clinical outcomes. Results 42 patients with a mean follow-up of 30.6 months were analyzed in this study. There was a statistically significant decrease in thalamus, caudate and putamen volumes, but not cerebellar cortical and pallidum volumes during the follow-up period. Baseline thalamus, caudate and putamen volumes predicted subsequent changes in the timed 25-ft walk test (p = 0.036) and MSFC (p = 0.024). There was a trend for an association between baseline caudate volume and subsequent change in the timed 25-ft walk test (p = 0.084). No association between baseline imaging and subsequent EDSS changes were seen. Conclusion Subcortical grey matter volumes at early stages of MS are associated with subsequent changes in disability measures.
AB - Background Atrophy of subcortical grey matter structures has been reported to be associated with clinical measures of disability in multiple sclerosis (MS) patients. It is not clear if the degree of tissue loss in patients with very early MS is associated with changes in disability measures. Objective To study the association between subcortical grey matter structure volumes and clinical disability outcomes. Methods Relapsing MS patients within 12 months of clinical onset were enrolled in a neuroprotection trial of riluzole versus placebo with up to 36 months of follow-up and serial brain MRI and clinical assessments. MRI metrics, including thalamic, putamen, caudate, pallidum and cerebellar cortical volume, were measured by an automated, custom-made FreeSurfer pipeline. Volumes were normalized for head size. Clinical measures included EDSS, MSFC scores and its components. Mixed model regression measured time trends and associations between imaging and clinical outcomes. Results 42 patients with a mean follow-up of 30.6 months were analyzed in this study. There was a statistically significant decrease in thalamus, caudate and putamen volumes, but not cerebellar cortical and pallidum volumes during the follow-up period. Baseline thalamus, caudate and putamen volumes predicted subsequent changes in the timed 25-ft walk test (p = 0.036) and MSFC (p = 0.024). There was a trend for an association between baseline caudate volume and subsequent change in the timed 25-ft walk test (p = 0.084). No association between baseline imaging and subsequent EDSS changes were seen. Conclusion Subcortical grey matter volumes at early stages of MS are associated with subsequent changes in disability measures.
KW - Ambulation
KW - Atrophy
KW - Grey matter
KW - Multiple sclerosis
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U2 - 10.1016/j.jns.2016.04.054
DO - 10.1016/j.jns.2016.04.054
M3 - Article
C2 - 27288812
AN - SCOPUS:84969551379
SN - 0022-510X
VL - 366
SP - 229
EP - 233
JO - Journal of the neurological sciences
JF - Journal of the neurological sciences
ER -