Subcortical grey matter volumes predict subsequent walking function in early multiple sclerosis

Bardia Nourbakhsh, Christina Azevedo, Amir Hadi Maghzi, Rebecca Spain, Daniel Pelletier, Emmanuelle Waubant

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background Atrophy of subcortical grey matter structures has been reported to be associated with clinical measures of disability in multiple sclerosis (MS) patients. It is not clear if the degree of tissue loss in patients with very early MS is associated with changes in disability measures. Objective To study the association between subcortical grey matter structure volumes and clinical disability outcomes. Methods Relapsing MS patients within 12 months of clinical onset were enrolled in a neuroprotection trial of riluzole versus placebo with up to 36 months of follow-up and serial brain MRI and clinical assessments. MRI metrics, including thalamic, putamen, caudate, pallidum and cerebellar cortical volume, were measured by an automated, custom-made FreeSurfer pipeline. Volumes were normalized for head size. Clinical measures included EDSS, MSFC scores and its components. Mixed model regression measured time trends and associations between imaging and clinical outcomes. Results 42 patients with a mean follow-up of 30.6 months were analyzed in this study. There was a statistically significant decrease in thalamus, caudate and putamen volumes, but not cerebellar cortical and pallidum volumes during the follow-up period. Baseline thalamus, caudate and putamen volumes predicted subsequent changes in the timed 25-ft walk test (p = 0.036) and MSFC (p = 0.024). There was a trend for an association between baseline caudate volume and subsequent change in the timed 25-ft walk test (p = 0.084). No association between baseline imaging and subsequent EDSS changes were seen. Conclusion Subcortical grey matter volumes at early stages of MS are associated with subsequent changes in disability measures.

Original languageEnglish (US)
Pages (from-to)229-233
Number of pages5
JournalJournal of the Neurological Sciences
Volume366
DOIs
StatePublished - Jul 15 2016

Fingerprint

Multiple Sclerosis
Walking
Putamen
Globus Pallidus
Thalamus
Riluzole
Atrophy
Head
Placebos
Gray Matter
Brain
Walk Test

Keywords

  • Ambulation
  • Atrophy
  • Grey matter
  • Multiple sclerosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Subcortical grey matter volumes predict subsequent walking function in early multiple sclerosis. / Nourbakhsh, Bardia; Azevedo, Christina; Maghzi, Amir Hadi; Spain, Rebecca; Pelletier, Daniel; Waubant, Emmanuelle.

In: Journal of the Neurological Sciences, Vol. 366, 15.07.2016, p. 229-233.

Research output: Contribution to journalArticle

Nourbakhsh, Bardia ; Azevedo, Christina ; Maghzi, Amir Hadi ; Spain, Rebecca ; Pelletier, Daniel ; Waubant, Emmanuelle. / Subcortical grey matter volumes predict subsequent walking function in early multiple sclerosis. In: Journal of the Neurological Sciences. 2016 ; Vol. 366. pp. 229-233.
@article{95e410089c1c4e52a71575fb1e01e6ed,
title = "Subcortical grey matter volumes predict subsequent walking function in early multiple sclerosis",
abstract = "Background Atrophy of subcortical grey matter structures has been reported to be associated with clinical measures of disability in multiple sclerosis (MS) patients. It is not clear if the degree of tissue loss in patients with very early MS is associated with changes in disability measures. Objective To study the association between subcortical grey matter structure volumes and clinical disability outcomes. Methods Relapsing MS patients within 12 months of clinical onset were enrolled in a neuroprotection trial of riluzole versus placebo with up to 36 months of follow-up and serial brain MRI and clinical assessments. MRI metrics, including thalamic, putamen, caudate, pallidum and cerebellar cortical volume, were measured by an automated, custom-made FreeSurfer pipeline. Volumes were normalized for head size. Clinical measures included EDSS, MSFC scores and its components. Mixed model regression measured time trends and associations between imaging and clinical outcomes. Results 42 patients with a mean follow-up of 30.6 months were analyzed in this study. There was a statistically significant decrease in thalamus, caudate and putamen volumes, but not cerebellar cortical and pallidum volumes during the follow-up period. Baseline thalamus, caudate and putamen volumes predicted subsequent changes in the timed 25-ft walk test (p = 0.036) and MSFC (p = 0.024). There was a trend for an association between baseline caudate volume and subsequent change in the timed 25-ft walk test (p = 0.084). No association between baseline imaging and subsequent EDSS changes were seen. Conclusion Subcortical grey matter volumes at early stages of MS are associated with subsequent changes in disability measures.",
keywords = "Ambulation, Atrophy, Grey matter, Multiple sclerosis",
author = "Bardia Nourbakhsh and Christina Azevedo and Maghzi, {Amir Hadi} and Rebecca Spain and Daniel Pelletier and Emmanuelle Waubant",
year = "2016",
month = "7",
day = "15",
doi = "10.1016/j.jns.2016.04.054",
language = "English (US)",
volume = "366",
pages = "229--233",
journal = "Journal of the Neurological Sciences",
issn = "0022-510X",
publisher = "Elsevier",

}

TY - JOUR

T1 - Subcortical grey matter volumes predict subsequent walking function in early multiple sclerosis

AU - Nourbakhsh, Bardia

AU - Azevedo, Christina

AU - Maghzi, Amir Hadi

AU - Spain, Rebecca

AU - Pelletier, Daniel

AU - Waubant, Emmanuelle

PY - 2016/7/15

Y1 - 2016/7/15

N2 - Background Atrophy of subcortical grey matter structures has been reported to be associated with clinical measures of disability in multiple sclerosis (MS) patients. It is not clear if the degree of tissue loss in patients with very early MS is associated with changes in disability measures. Objective To study the association between subcortical grey matter structure volumes and clinical disability outcomes. Methods Relapsing MS patients within 12 months of clinical onset were enrolled in a neuroprotection trial of riluzole versus placebo with up to 36 months of follow-up and serial brain MRI and clinical assessments. MRI metrics, including thalamic, putamen, caudate, pallidum and cerebellar cortical volume, were measured by an automated, custom-made FreeSurfer pipeline. Volumes were normalized for head size. Clinical measures included EDSS, MSFC scores and its components. Mixed model regression measured time trends and associations between imaging and clinical outcomes. Results 42 patients with a mean follow-up of 30.6 months were analyzed in this study. There was a statistically significant decrease in thalamus, caudate and putamen volumes, but not cerebellar cortical and pallidum volumes during the follow-up period. Baseline thalamus, caudate and putamen volumes predicted subsequent changes in the timed 25-ft walk test (p = 0.036) and MSFC (p = 0.024). There was a trend for an association between baseline caudate volume and subsequent change in the timed 25-ft walk test (p = 0.084). No association between baseline imaging and subsequent EDSS changes were seen. Conclusion Subcortical grey matter volumes at early stages of MS are associated with subsequent changes in disability measures.

AB - Background Atrophy of subcortical grey matter structures has been reported to be associated with clinical measures of disability in multiple sclerosis (MS) patients. It is not clear if the degree of tissue loss in patients with very early MS is associated with changes in disability measures. Objective To study the association between subcortical grey matter structure volumes and clinical disability outcomes. Methods Relapsing MS patients within 12 months of clinical onset were enrolled in a neuroprotection trial of riluzole versus placebo with up to 36 months of follow-up and serial brain MRI and clinical assessments. MRI metrics, including thalamic, putamen, caudate, pallidum and cerebellar cortical volume, were measured by an automated, custom-made FreeSurfer pipeline. Volumes were normalized for head size. Clinical measures included EDSS, MSFC scores and its components. Mixed model regression measured time trends and associations between imaging and clinical outcomes. Results 42 patients with a mean follow-up of 30.6 months were analyzed in this study. There was a statistically significant decrease in thalamus, caudate and putamen volumes, but not cerebellar cortical and pallidum volumes during the follow-up period. Baseline thalamus, caudate and putamen volumes predicted subsequent changes in the timed 25-ft walk test (p = 0.036) and MSFC (p = 0.024). There was a trend for an association between baseline caudate volume and subsequent change in the timed 25-ft walk test (p = 0.084). No association between baseline imaging and subsequent EDSS changes were seen. Conclusion Subcortical grey matter volumes at early stages of MS are associated with subsequent changes in disability measures.

KW - Ambulation

KW - Atrophy

KW - Grey matter

KW - Multiple sclerosis

UR - http://www.scopus.com/inward/record.url?scp=84969551379&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84969551379&partnerID=8YFLogxK

U2 - 10.1016/j.jns.2016.04.054

DO - 10.1016/j.jns.2016.04.054

M3 - Article

C2 - 27288812

AN - SCOPUS:84969551379

VL - 366

SP - 229

EP - 233

JO - Journal of the Neurological Sciences

JF - Journal of the Neurological Sciences

SN - 0022-510X

ER -