Subclinical thyroid dysfunction and frailty among older men

Vanessa S. Virgini, Nicolas Rodondi, Peggy M. Cawthon, Stephanie Litwack Harrison, Andrew R. Hoffman, Eric Orwoll, Kristine E. Ensrud, Douglas C. Bauer

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19 Scopus citations

Abstract

Context: Both subclinical thyroid dysfunction and frailty are common among older individuals, but data on the relationship between these 2 conditions are conflicting. Objective: The purpose of this study was to assess the cross-sectional and prospective associations between subclinical thyroid dysfunction and frailty and the 5 frailty subdomains (sarcopenia, weakness, slowness, exhaustion, and low activity). Setting and Design: The Osteoporotic Fractures in Men Study is a prospective cohort study. Participants: Men older than 65 years (n = 1455) were classified into 3 groups of thyroid status: subclinical hyperthyroidism (n = 26, 1.8%), subclinical hypothyroidism (n = 102, 7.0%), and euthyroidism (n = 1327, 91.2%). MainOutcomeMeasures: Frailty was defined using a slightly modified Cardiovascular Health Study Index: men with 3 or more criteria were considered frail, men with 1 to 2 criteria were considered intermediately frail, and men with no criteria were considered robust. We assessed the crosssectional relationship between baseline thyroid function and the 3 categories of frailty status (robust/intermediate/frail) as well as the prospective association between baseline thyroid function and subsequent frailty status and mortality after a 5-year follow-up. Results: At baseline, compared with euthyroid participants,menwith subclinical hyperthyroidism had an increased likelihood of greater frailty status (adjusted odds ratio, 2.48; 95% confidence interval, 1.15-5.34), particularly among men aged

Original languageEnglish (US)
Pages (from-to)4524-4532
Number of pages9
JournalJournal of Clinical Endocrinology and Metabolism
Volume100
Issue number12
DOIs
StatePublished - Dec 1 2015

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ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism

Cite this

Virgini, V. S., Rodondi, N., Cawthon, P. M., Harrison, S. L., Hoffman, A. R., Orwoll, E., Ensrud, K. E., & Bauer, D. C. (2015). Subclinical thyroid dysfunction and frailty among older men. Journal of Clinical Endocrinology and Metabolism, 100(12), 4524-4532. https://doi.org/10.1210/jc.2015-3191