Subarachnoid hemorrhage pattern predicts acute cerebral blood flow response in the rat

Jesse J. Liu; Jeffrey S. Raskin; Robin McFarlane; Ravi Samatham; Justin S. Cetas

doi:10.1007/978-3-030-04615-6_14

Subarachnoid hemorrhage pattern predicts acute cerebral blood flow response in the rat

Jesse J. Liu, Jeffrey S. Raskin, Robin McFarlane, Ravi Samatham, Justin S. Cetas

Research output: Chapter in Book/Report/Conference proceeding › Chapter

6 Scopus citations

Abstract

There is considerable variability in the presentation of patients with acute subarachnoid hemorrhage (aSAH). Evidence suggests that a thick, diffuse clot better predicts the development of delayed cerebral ischemia and poor outcomes. In a rodent model of acute SAH, we directly measured the effects of the volume of blood injected versus the pattern of distribution of hemorrhage in the subarachnoid space on markers of early brain injury, namely, cerebral blood flow (CBF), cerebrospinal fluid (CSF) concentrations of P450 eicosanoids and catecholamines, and cortical spreading depolarizations (CSDs). There is a significant decrease in CBF, an increase in CSF biomarkers, and a trend toward increasing frequency and severity of CSDs when grouped by severity of hemorrhage but not by volume of blood injected. In severe hemorrhage grade animals, there was a progressive decrease in CBF after successive CSD events. These results suggest that the pattern of SAH (thick diffuse clots) correlates with the “clinical” severity of SAH.

Original language	English (US)
Title of host publication	Acta Neurochirurgica, Supplementum
Publisher	Springer-Verlag Wien
Pages	83-89
Number of pages	7
DOIs	https://doi.org/10.1007/978-3-030-04615-6_14
State	Published - 2020

Publication series

Name	Acta Neurochirurgica, Supplementum
Volume	127
ISSN (Print)	0065-1419
ISSN (Electronic)	2197-8395

Keywords

14,15-EET
20-HETE
Cortical spreading depolarization
Early brain injury
P450 eicosanoids
Stroke glymphatic
Subarachnoid hemorrhage

ASJC Scopus subject areas

Surgery
Clinical Neurology

Access to Document

10.1007/978-3-030-04615-6_14

Cite this

@inbook{6540879dc79740ae9005b28c2a66bbed,

title = "Subarachnoid hemorrhage pattern predicts acute cerebral blood flow response in the rat",

abstract = "There is considerable variability in the presentation of patients with acute subarachnoid hemorrhage (aSAH). Evidence suggests that a thick, diffuse clot better predicts the development of delayed cerebral ischemia and poor outcomes. In a rodent model of acute SAH, we directly measured the effects of the volume of blood injected versus the pattern of distribution of hemorrhage in the subarachnoid space on markers of early brain injury, namely, cerebral blood flow (CBF), cerebrospinal fluid (CSF) concentrations of P450 eicosanoids and catecholamines, and cortical spreading depolarizations (CSDs). There is a significant decrease in CBF, an increase in CSF biomarkers, and a trend toward increasing frequency and severity of CSDs when grouped by severity of hemorrhage but not by volume of blood injected. In severe hemorrhage grade animals, there was a progressive decrease in CBF after successive CSD events. These results suggest that the pattern of SAH (thick diffuse clots) correlates with the “clinical” severity of SAH.",

keywords = "14,15-EET, 20-HETE, Cortical spreading depolarization, Early brain injury, P450 eicosanoids, Stroke glymphatic, Subarachnoid hemorrhage",

author = "Liu, {Jesse J.} and Raskin, {Jeffrey S.} and Robin McFarlane and Ravi Samatham and Cetas, {Justin S.}",

note = "Publisher Copyright: {\textcopyright} Springer Nature Switzerland AG 2020.",

year = "2020",

doi = "10.1007/978-3-030-04615-6_14",

language = "English (US)",

series = "Acta Neurochirurgica, Supplementum",

publisher = "Springer-Verlag Wien",

pages = "83--89",

booktitle = "Acta Neurochirurgica, Supplementum",

}

TY - CHAP

T1 - Subarachnoid hemorrhage pattern predicts acute cerebral blood flow response in the rat

AU - Liu, Jesse J.

AU - Raskin, Jeffrey S.

AU - McFarlane, Robin

AU - Samatham, Ravi

AU - Cetas, Justin S.

N1 - Publisher Copyright: © Springer Nature Switzerland AG 2020.

PY - 2020

Y1 - 2020

N2 - There is considerable variability in the presentation of patients with acute subarachnoid hemorrhage (aSAH). Evidence suggests that a thick, diffuse clot better predicts the development of delayed cerebral ischemia and poor outcomes. In a rodent model of acute SAH, we directly measured the effects of the volume of blood injected versus the pattern of distribution of hemorrhage in the subarachnoid space on markers of early brain injury, namely, cerebral blood flow (CBF), cerebrospinal fluid (CSF) concentrations of P450 eicosanoids and catecholamines, and cortical spreading depolarizations (CSDs). There is a significant decrease in CBF, an increase in CSF biomarkers, and a trend toward increasing frequency and severity of CSDs when grouped by severity of hemorrhage but not by volume of blood injected. In severe hemorrhage grade animals, there was a progressive decrease in CBF after successive CSD events. These results suggest that the pattern of SAH (thick diffuse clots) correlates with the “clinical” severity of SAH.

AB - There is considerable variability in the presentation of patients with acute subarachnoid hemorrhage (aSAH). Evidence suggests that a thick, diffuse clot better predicts the development of delayed cerebral ischemia and poor outcomes. In a rodent model of acute SAH, we directly measured the effects of the volume of blood injected versus the pattern of distribution of hemorrhage in the subarachnoid space on markers of early brain injury, namely, cerebral blood flow (CBF), cerebrospinal fluid (CSF) concentrations of P450 eicosanoids and catecholamines, and cortical spreading depolarizations (CSDs). There is a significant decrease in CBF, an increase in CSF biomarkers, and a trend toward increasing frequency and severity of CSDs when grouped by severity of hemorrhage but not by volume of blood injected. In severe hemorrhage grade animals, there was a progressive decrease in CBF after successive CSD events. These results suggest that the pattern of SAH (thick diffuse clots) correlates with the “clinical” severity of SAH.

KW - 14,15-EET

KW - 20-HETE

KW - Cortical spreading depolarization

KW - Early brain injury

KW - P450 eicosanoids

KW - Stroke glymphatic

KW - Subarachnoid hemorrhage

UR - http://www.scopus.com/inward/record.url?scp=85071281992&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85071281992&partnerID=8YFLogxK

U2 - 10.1007/978-3-030-04615-6_14

DO - 10.1007/978-3-030-04615-6_14

M3 - Chapter

C2 - 31407068

AN - SCOPUS:85071281992

T3 - Acta Neurochirurgica, Supplementum

SP - 83

EP - 89

BT - Acta Neurochirurgica, Supplementum

PB - Springer-Verlag Wien

ER -