Studying salmonellae and yersiniae host-pathogen interactions using integrated 'omics and modeling

Charles Ansong, Brooke L. Deatherage, Daniel Hyduke, Brian Schmidt, Jason E. McDermott, Marcus B. Jones, Sadhana Chauhan, Pep Charusanti, Young Mo Kim, Ernesto S. Nakayasu, Jie Li, Afshan Kidwai, George Niemann, Roslyn N. Brown, Thomas O. Metz, Kathleen McAteer, Fred Heffron, Scott N. Peterson, Vladimir Motin, Bernhard O. PalssonRichard D. Smith, Joshua N. Adkins

    Research output: Chapter in Book/Report/Conference proceedingChapter

    8 Citations (Scopus)

    Abstract

    Salmonella and Yersinia are two distantly related genera containing species with wide host-range specificity and pathogenic capacity. The metabolic complexity of these organisms facilitates robust lifestyles both outside of and within animal hosts. Using a pathogen-centric systems biology approach, we are combining a multi-omics (transcriptomics, proteomics, metabolomics) strategy to define properties of these pathogens under a variety of conditions including those that mimic the environments encountered during pathogenesis. These high-dimensional omics datasets are being integrated in selected ways to improve genome annotations, discover novel virulence-related factors, and model growth under infectious states. We will review the evolving technological approaches toward understanding complex microbial life through multi-omic measurements and integration, while highlighting some of our most recent successes in this area.

    Original languageEnglish (US)
    Title of host publicationCurrent Topics in Microbiology and Immunology
    Pages21-41
    Number of pages21
    Volume363
    DOIs
    StatePublished - 2012

    Publication series

    NameCurrent Topics in Microbiology and Immunology
    Volume363
    ISSN (Print)0070217X

    Fingerprint

    Host-Pathogen Interactions
    Yersinia
    Host Specificity
    Salmonella
    Metabolomics
    Systems Biology
    Virulence Factors
    Proteomics
    Life Style
    Genome
    Growth
    Datasets

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Microbiology (medical)
    • Immunology
    • Microbiology

    Cite this

    Ansong, C., Deatherage, B. L., Hyduke, D., Schmidt, B., McDermott, J. E., Jones, M. B., ... Adkins, J. N. (2012). Studying salmonellae and yersiniae host-pathogen interactions using integrated 'omics and modeling. In Current Topics in Microbiology and Immunology (Vol. 363, pp. 21-41). (Current Topics in Microbiology and Immunology; Vol. 363). https://doi.org/10.1007/82-2012-247

    Studying salmonellae and yersiniae host-pathogen interactions using integrated 'omics and modeling. / Ansong, Charles; Deatherage, Brooke L.; Hyduke, Daniel; Schmidt, Brian; McDermott, Jason E.; Jones, Marcus B.; Chauhan, Sadhana; Charusanti, Pep; Kim, Young Mo; Nakayasu, Ernesto S.; Li, Jie; Kidwai, Afshan; Niemann, George; Brown, Roslyn N.; Metz, Thomas O.; McAteer, Kathleen; Heffron, Fred; Peterson, Scott N.; Motin, Vladimir; Palsson, Bernhard O.; Smith, Richard D.; Adkins, Joshua N.

    Current Topics in Microbiology and Immunology. Vol. 363 2012. p. 21-41 (Current Topics in Microbiology and Immunology; Vol. 363).

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Ansong, C, Deatherage, BL, Hyduke, D, Schmidt, B, McDermott, JE, Jones, MB, Chauhan, S, Charusanti, P, Kim, YM, Nakayasu, ES, Li, J, Kidwai, A, Niemann, G, Brown, RN, Metz, TO, McAteer, K, Heffron, F, Peterson, SN, Motin, V, Palsson, BO, Smith, RD & Adkins, JN 2012, Studying salmonellae and yersiniae host-pathogen interactions using integrated 'omics and modeling. in Current Topics in Microbiology and Immunology. vol. 363, Current Topics in Microbiology and Immunology, vol. 363, pp. 21-41. https://doi.org/10.1007/82-2012-247
    Ansong C, Deatherage BL, Hyduke D, Schmidt B, McDermott JE, Jones MB et al. Studying salmonellae and yersiniae host-pathogen interactions using integrated 'omics and modeling. In Current Topics in Microbiology and Immunology. Vol. 363. 2012. p. 21-41. (Current Topics in Microbiology and Immunology). https://doi.org/10.1007/82-2012-247
    Ansong, Charles ; Deatherage, Brooke L. ; Hyduke, Daniel ; Schmidt, Brian ; McDermott, Jason E. ; Jones, Marcus B. ; Chauhan, Sadhana ; Charusanti, Pep ; Kim, Young Mo ; Nakayasu, Ernesto S. ; Li, Jie ; Kidwai, Afshan ; Niemann, George ; Brown, Roslyn N. ; Metz, Thomas O. ; McAteer, Kathleen ; Heffron, Fred ; Peterson, Scott N. ; Motin, Vladimir ; Palsson, Bernhard O. ; Smith, Richard D. ; Adkins, Joshua N. / Studying salmonellae and yersiniae host-pathogen interactions using integrated 'omics and modeling. Current Topics in Microbiology and Immunology. Vol. 363 2012. pp. 21-41 (Current Topics in Microbiology and Immunology).
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    AU - McDermott, Jason E.

    AU - Jones, Marcus B.

    AU - Chauhan, Sadhana

    AU - Charusanti, Pep

    AU - Kim, Young Mo

    AU - Nakayasu, Ernesto S.

    AU - Li, Jie

    AU - Kidwai, Afshan

    AU - Niemann, George

    AU - Brown, Roslyn N.

    AU - Metz, Thomas O.

    AU - McAteer, Kathleen

    AU - Heffron, Fred

    AU - Peterson, Scott N.

    AU - Motin, Vladimir

    AU - Palsson, Bernhard O.

    AU - Smith, Richard D.

    AU - Adkins, Joshua N.

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