Studying Life Effects & Effectiveness of Palatopharyngoplasty (SLEEP) study: Subjective outcomes of isolated uvulopalatopharyngoplasty

Edward M. Weaver; B. Tucker Woodson; Bevan Yueh; Timothy Smith; Michael G. Stewart; Maureen Hannley; Kristine Schulz; Milesh M. Patel; David Witsell; David C. Brodner; Karen Calhoun; John S. Donovan; Mark Gibbons; Philip T. Ho; James Jarrett; Jonas Johnson; F. P.J. Langford; Jonathan D. McGinn; Mary Mitskavich; Steven Y. Park; Regina Walker; Samuel Welch; Kathleen Yaremchuk; David I. Astrachan; David R. Bruce; Gary A. Buxa; Cecelia C. Damask; Dwight Ellerbe; Joseph Giebfried; Bruce R. Gordon; Andrew Gould; Robert E. Harley; Wayne Harsha; Kenneth Hodge; John Houck; Sean Houston; Ofer Jacobowitz; James E. Kallman; Eric J. Kezirian; Alan Kominsky; Richard Lenz; Jennifer Lynch; Nicole Maronian; John Morris; Lionel M. Nelson; Michael Y. Parker; Mark Reinke; Richard Scher; Frederic Schmidt; Douglas Sorensen; Jordan Stern; David L. Steward; Richard Waguespack; David Wexler; Stefan Zechowy; Larry Zieske

doi:10.1177/0194599810394982

Studying Life Effects & Effectiveness of Palatopharyngoplasty (SLEEP) study: Subjective outcomes of isolated uvulopalatopharyngoplasty

Edward M. Weaver, B. Tucker Woodson, Bevan Yueh, Timothy Smith, Michael G. Stewart, Maureen Hannley, Kristine Schulz, Milesh M. Patel, David Witsell, David C. Brodner, Karen Calhoun, John S. Donovan, Mark Gibbons, Philip T. Ho, James Jarrett, Jonas Johnson, F. P.J. Langford, Jonathan D. McGinn, Mary Mitskavich, Steven Y. ParkRegina Walker, Samuel Welch, Kathleen Yaremchuk, David I. Astrachan, David R. Bruce, Gary A. Buxa, Cecelia C. Damask, Dwight Ellerbe, Joseph Giebfried, Bruce R. Gordon, Andrew Gould, Robert E. Harley, Wayne Harsha, Kenneth Hodge, John Houck, Sean Houston, Ofer Jacobowitz, James E. Kallman, Eric J. Kezirian, Alan Kominsky, Richard Lenz, Jennifer Lynch, Nicole Maronian, John Morris, Lionel M. Nelson, Michael Y. Parker, Mark Reinke, Richard Scher, Frederic Schmidt, Douglas Sorensen, Jordan Stern, David L. Steward, Richard Waguespack, David Wexler, Stefan Zechowy, Larry Zieske

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Objective. To test the hypothesis that uvulopalatopharyngoplasty (UPPP) improves sleep apnea-related quality of life (measured on the Functional Outcomes of Sleep Questionnaire [FOSQ]) at 3-month follow-up. Secondary objectives were to test (1) the stability of the outcomes at 6 months, (2) the effect on global sleep apnea quality-of-life change, and (3) the effect on sleep apnea symptoms. Study Design. Multicenter, prospective, longitudinal case series. Setting. Diverse university- and community-based otolaryngology practices. Subjects and Methods. The cohort included 68 patients from 17 practices, with a mean ± standard deviation age of 44 ± 12 years and mean apnea-hypopnea index of 35 ± 32 events/hour. All patients underwent UPPP, defined as an open procedure modifying the shape and size of the palate, pharynx, and uvula, with or without tonsillectomy. Baseline data were collected on site before surgery, and outcome data were collected by mail 3 and 6 months after surgery, with follow-up rates of 51% and 50%, respectively. Results. FOSQ scores improved from 14.3 ± 3.4 (scale 5-20, normal ≥17.9) at baseline to 17.2 ± 2.7 at 3 months (mean improvement 2.9; 95% confidence interval, 1.8-4.0; P < .001) and 17.5 ± 2.5 at 6 months (mean improvement 3.1; 95% confidence interval, 2.0-4.2; P < .001). All quality-of-life and symptom measures improved significantly at 3 and 6 months (all P < .05). Conclusion. This prospective, multicenter, university- and community-based study provides evidence that UPPP significantly improves disease-specific quality of life and sleep apnea symptoms in patients with sleep apnea. Validity may be limited by significant loss to follow-up and absence of an unoperated control group.

Original language	English (US)
Pages (from-to)	623-631
Number of pages	9
Journal	Otolaryngology - Head and Neck Surgery
Volume	144
Issue number	4
DOIs	https://doi.org/10.1177/0194599810394982
State	Published - Apr 2011
Externally published	Yes

Keywords

Obstructive sleep apnea
Palatopharyngoplasty
Quality of life
Sleep apnea
Sleep-disordered breathing
Tonsillectomy
Uvulopalatopharyngoplasty

ASJC Scopus subject areas

Surgery
Otorhinolaryngology

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10.1177/0194599810394982

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Weaver, E. M., Woodson, B. T., Yueh, B., Smith, T., Stewart, M. G., Hannley, M., Schulz, K., Patel, M. M., Witsell, D., Brodner, D. C., Calhoun, K., Donovan, J. S., Gibbons, M., Ho, P. T., Jarrett, J., Johnson, J., Langford, F. P. J., McGinn, J. D., Mitskavich, M., ... Zieske, L. (2011). Studying Life Effects & Effectiveness of Palatopharyngoplasty (SLEEP) study: Subjective outcomes of isolated uvulopalatopharyngoplasty. Otolaryngology - Head and Neck Surgery, 144(4), 623-631. https://doi.org/10.1177/0194599810394982

Weaver, EM, Woodson, BT, Yueh, B, Smith, T, Stewart, MG, Hannley, M, Schulz, K, Patel, MM, Witsell, D, Brodner, DC, Calhoun, K, Donovan, JS, Gibbons, M, Ho, PT, Jarrett, J, Johnson, J, Langford, FPJ, McGinn, JD, Mitskavich, M, Park, SY, Walker, R, Welch, S, Yaremchuk, K, Astrachan, DI, Bruce, DR, Buxa, GA, Damask, CC, Ellerbe, D, Giebfried, J, Gordon, BR, Gould, A, Harley, RE, Harsha, W, Hodge, K, Houck, J, Houston, S, Jacobowitz, O, Kallman, JE, Kezirian, EJ, Kominsky, A, Lenz, R, Lynch, J, Maronian, N, Morris, J, Nelson, LM, Parker, MY, Reinke, M, Scher, R, Schmidt, F, Sorensen, D, Stern, J, Steward, DL, Waguespack, R, Wexler, D, Zechowy, S & Zieske, L 2011, 'Studying Life Effects & Effectiveness of Palatopharyngoplasty (SLEEP) study: Subjective outcomes of isolated uvulopalatopharyngoplasty', Otolaryngology - Head and Neck Surgery, vol. 144, no. 4, pp. 623-631. https://doi.org/10.1177/0194599810394982

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title = "Studying Life Effects & Effectiveness of Palatopharyngoplasty (SLEEP) study: Subjective outcomes of isolated uvulopalatopharyngoplasty",

abstract = "Objective. To test the hypothesis that uvulopalatopharyngoplasty (UPPP) improves sleep apnea-related quality of life (measured on the Functional Outcomes of Sleep Questionnaire [FOSQ]) at 3-month follow-up. Secondary objectives were to test (1) the stability of the outcomes at 6 months, (2) the effect on global sleep apnea quality-of-life change, and (3) the effect on sleep apnea symptoms. Study Design. Multicenter, prospective, longitudinal case series. Setting. Diverse university- and community-based otolaryngology practices. Subjects and Methods. The cohort included 68 patients from 17 practices, with a mean ± standard deviation age of 44 ± 12 years and mean apnea-hypopnea index of 35 ± 32 events/hour. All patients underwent UPPP, defined as an open procedure modifying the shape and size of the palate, pharynx, and uvula, with or without tonsillectomy. Baseline data were collected on site before surgery, and outcome data were collected by mail 3 and 6 months after surgery, with follow-up rates of 51% and 50%, respectively. Results. FOSQ scores improved from 14.3 ± 3.4 (scale 5-20, normal ≥17.9) at baseline to 17.2 ± 2.7 at 3 months (mean improvement 2.9; 95% confidence interval, 1.8-4.0; P < .001) and 17.5 ± 2.5 at 6 months (mean improvement 3.1; 95% confidence interval, 2.0-4.2; P < .001). All quality-of-life and symptom measures improved significantly at 3 and 6 months (all P < .05). Conclusion. This prospective, multicenter, university- and community-based study provides evidence that UPPP significantly improves disease-specific quality of life and sleep apnea symptoms in patients with sleep apnea. Validity may be limited by significant loss to follow-up and absence of an unoperated control group.",

keywords = "Obstructive sleep apnea, Palatopharyngoplasty, Quality of life, Sleep apnea, Sleep-disordered breathing, Tonsillectomy, Uvulopalatopharyngoplasty",

author = "Weaver, {Edward M.} and Woodson, {B. Tucker} and Bevan Yueh and Timothy Smith and Stewart, {Michael G.} and Maureen Hannley and Kristine Schulz and Patel, {Milesh M.} and David Witsell and Brodner, {David C.} and Karen Calhoun and Donovan, {John S.} and Mark Gibbons and Ho, {Philip T.} and James Jarrett and Jonas Johnson and Langford, {F. P.J.} and McGinn, {Jonathan D.} and Mary Mitskavich and Park, {Steven Y.} and Regina Walker and Samuel Welch and Kathleen Yaremchuk and Astrachan, {David I.} and Bruce, {David R.} and Buxa, {Gary A.} and Damask, {Cecelia C.} and Dwight Ellerbe and Joseph Giebfried and Gordon, {Bruce R.} and Andrew Gould and Harley, {Robert E.} and Wayne Harsha and Kenneth Hodge and John Houck and Sean Houston and Ofer Jacobowitz and Kallman, {James E.} and Kezirian, {Eric J.} and Alan Kominsky and Richard Lenz and Jennifer Lynch and Nicole Maronian and John Morris and Nelson, {Lionel M.} and Parker, {Michael Y.} and Mark Reinke and Richard Scher and Frederic Schmidt and Douglas Sorensen and Jordan Stern and Steward, {David L.} and Richard Waguespack and David Wexler and Stefan Zechowy and Larry Zieske",

year = "2011",

month = apr,

doi = "10.1177/0194599810394982",

language = "English (US)",

volume = "144",

pages = "623--631",

journal = "Otolaryngology - Head and Neck Surgery (United States)",

issn = "0194-5998",

publisher = "Mosby Inc.",

number = "4",

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TY - JOUR

T1 - Studying Life Effects & Effectiveness of Palatopharyngoplasty (SLEEP) study

T2 - Subjective outcomes of isolated uvulopalatopharyngoplasty

AU - Weaver, Edward M.

AU - Woodson, B. Tucker

AU - Yueh, Bevan

AU - Smith, Timothy

AU - Stewart, Michael G.

AU - Hannley, Maureen

AU - Schulz, Kristine

AU - Patel, Milesh M.

AU - Witsell, David

AU - Brodner, David C.

AU - Calhoun, Karen

AU - Donovan, John S.

AU - Gibbons, Mark

AU - Ho, Philip T.

AU - Jarrett, James

AU - Johnson, Jonas

AU - Langford, F. P.J.

AU - McGinn, Jonathan D.

AU - Mitskavich, Mary

AU - Park, Steven Y.

AU - Walker, Regina

AU - Welch, Samuel

AU - Yaremchuk, Kathleen

AU - Astrachan, David I.

AU - Bruce, David R.

AU - Buxa, Gary A.

AU - Damask, Cecelia C.

AU - Ellerbe, Dwight

AU - Giebfried, Joseph

AU - Gordon, Bruce R.

AU - Gould, Andrew

AU - Harley, Robert E.

AU - Harsha, Wayne

AU - Hodge, Kenneth

AU - Houck, John

AU - Houston, Sean

AU - Jacobowitz, Ofer

AU - Kallman, James E.

AU - Kezirian, Eric J.

AU - Kominsky, Alan

AU - Lenz, Richard

AU - Lynch, Jennifer

AU - Maronian, Nicole

AU - Morris, John

AU - Nelson, Lionel M.

AU - Parker, Michael Y.

AU - Reinke, Mark

AU - Scher, Richard

AU - Schmidt, Frederic

AU - Sorensen, Douglas

AU - Stern, Jordan

AU - Steward, David L.

AU - Waguespack, Richard

AU - Wexler, David

AU - Zechowy, Stefan

AU - Zieske, Larry

PY - 2011/4

Y1 - 2011/4

N2 - Objective. To test the hypothesis that uvulopalatopharyngoplasty (UPPP) improves sleep apnea-related quality of life (measured on the Functional Outcomes of Sleep Questionnaire [FOSQ]) at 3-month follow-up. Secondary objectives were to test (1) the stability of the outcomes at 6 months, (2) the effect on global sleep apnea quality-of-life change, and (3) the effect on sleep apnea symptoms. Study Design. Multicenter, prospective, longitudinal case series. Setting. Diverse university- and community-based otolaryngology practices. Subjects and Methods. The cohort included 68 patients from 17 practices, with a mean ± standard deviation age of 44 ± 12 years and mean apnea-hypopnea index of 35 ± 32 events/hour. All patients underwent UPPP, defined as an open procedure modifying the shape and size of the palate, pharynx, and uvula, with or without tonsillectomy. Baseline data were collected on site before surgery, and outcome data were collected by mail 3 and 6 months after surgery, with follow-up rates of 51% and 50%, respectively. Results. FOSQ scores improved from 14.3 ± 3.4 (scale 5-20, normal ≥17.9) at baseline to 17.2 ± 2.7 at 3 months (mean improvement 2.9; 95% confidence interval, 1.8-4.0; P < .001) and 17.5 ± 2.5 at 6 months (mean improvement 3.1; 95% confidence interval, 2.0-4.2; P < .001). All quality-of-life and symptom measures improved significantly at 3 and 6 months (all P < .05). Conclusion. This prospective, multicenter, university- and community-based study provides evidence that UPPP significantly improves disease-specific quality of life and sleep apnea symptoms in patients with sleep apnea. Validity may be limited by significant loss to follow-up and absence of an unoperated control group.

AB - Objective. To test the hypothesis that uvulopalatopharyngoplasty (UPPP) improves sleep apnea-related quality of life (measured on the Functional Outcomes of Sleep Questionnaire [FOSQ]) at 3-month follow-up. Secondary objectives were to test (1) the stability of the outcomes at 6 months, (2) the effect on global sleep apnea quality-of-life change, and (3) the effect on sleep apnea symptoms. Study Design. Multicenter, prospective, longitudinal case series. Setting. Diverse university- and community-based otolaryngology practices. Subjects and Methods. The cohort included 68 patients from 17 practices, with a mean ± standard deviation age of 44 ± 12 years and mean apnea-hypopnea index of 35 ± 32 events/hour. All patients underwent UPPP, defined as an open procedure modifying the shape and size of the palate, pharynx, and uvula, with or without tonsillectomy. Baseline data were collected on site before surgery, and outcome data were collected by mail 3 and 6 months after surgery, with follow-up rates of 51% and 50%, respectively. Results. FOSQ scores improved from 14.3 ± 3.4 (scale 5-20, normal ≥17.9) at baseline to 17.2 ± 2.7 at 3 months (mean improvement 2.9; 95% confidence interval, 1.8-4.0; P < .001) and 17.5 ± 2.5 at 6 months (mean improvement 3.1; 95% confidence interval, 2.0-4.2; P < .001). All quality-of-life and symptom measures improved significantly at 3 and 6 months (all P < .05). Conclusion. This prospective, multicenter, university- and community-based study provides evidence that UPPP significantly improves disease-specific quality of life and sleep apnea symptoms in patients with sleep apnea. Validity may be limited by significant loss to follow-up and absence of an unoperated control group.

KW - Obstructive sleep apnea

KW - Palatopharyngoplasty

KW - Quality of life

KW - Sleep apnea

KW - Sleep-disordered breathing

KW - Tonsillectomy

KW - Uvulopalatopharyngoplasty

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Studying Life Effects & Effectiveness of Palatopharyngoplasty (SLEEP) study: Subjective outcomes of isolated uvulopalatopharyngoplasty

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