@article{4222fbd63dc946cdb5778a9bf22a92cd,
title = "Studying Life Effects & Effectiveness of Palatopharyngoplasty (SLEEP) study: Subjective outcomes of isolated uvulopalatopharyngoplasty",
abstract = "Objective. To test the hypothesis that uvulopalatopharyngoplasty (UPPP) improves sleep apnea-related quality of life (measured on the Functional Outcomes of Sleep Questionnaire [FOSQ]) at 3-month follow-up. Secondary objectives were to test (1) the stability of the outcomes at 6 months, (2) the effect on global sleep apnea quality-of-life change, and (3) the effect on sleep apnea symptoms. Study Design. Multicenter, prospective, longitudinal case series. Setting. Diverse university- and community-based otolaryngology practices. Subjects and Methods. The cohort included 68 patients from 17 practices, with a mean ± standard deviation age of 44 ± 12 years and mean apnea-hypopnea index of 35 ± 32 events/hour. All patients underwent UPPP, defined as an open procedure modifying the shape and size of the palate, pharynx, and uvula, with or without tonsillectomy. Baseline data were collected on site before surgery, and outcome data were collected by mail 3 and 6 months after surgery, with follow-up rates of 51% and 50%, respectively. Results. FOSQ scores improved from 14.3 ± 3.4 (scale 5-20, normal ≥17.9) at baseline to 17.2 ± 2.7 at 3 months (mean improvement 2.9; 95% confidence interval, 1.8-4.0; P < .001) and 17.5 ± 2.5 at 6 months (mean improvement 3.1; 95% confidence interval, 2.0-4.2; P < .001). All quality-of-life and symptom measures improved significantly at 3 and 6 months (all P < .05). Conclusion. This prospective, multicenter, university- and community-based study provides evidence that UPPP significantly improves disease-specific quality of life and sleep apnea symptoms in patients with sleep apnea. Validity may be limited by significant loss to follow-up and absence of an unoperated control group.",
keywords = "Obstructive sleep apnea, Palatopharyngoplasty, Quality of life, Sleep apnea, Sleep-disordered breathing, Tonsillectomy, Uvulopalatopharyngoplasty",
author = "Weaver, {Edward M.} and Woodson, {B. Tucker} and Bevan Yueh and Timothy Smith and Stewart, {Michael G.} and Maureen Hannley and Kristine Schulz and Patel, {Milesh M.} and David Witsell and Brodner, {David C.} and Karen Calhoun and Donovan, {John S.} and Mark Gibbons and Ho, {Philip T.} and James Jarrett and Jonas Johnson and Langford, {F. P.J.} and McGinn, {Jonathan D.} and Mary Mitskavich and Park, {Steven Y.} and Regina Walker and Samuel Welch and Kathleen Yaremchuk and Astrachan, {David I.} and Bruce, {David R.} and Buxa, {Gary A.} and Damask, {Cecelia C.} and Dwight Ellerbe and Joseph Giebfried and Gordon, {Bruce R.} and Andrew Gould and Harley, {Robert E.} and Wayne Harsha and Kenneth Hodge and John Houck and Sean Houston and Ofer Jacobowitz and Kallman, {James E.} and Kezirian, {Eric J.} and Alan Kominsky and Richard Lenz and Jennifer Lynch and Nicole Maronian and John Morris and Nelson, {Lionel M.} and Parker, {Michael Y.} and Mark Reinke and Richard Scher and Frederic Schmidt and Douglas Sorensen and Jordan Stern and Steward, {David L.} and Richard Waguespack and David Wexler and Stefan Zechowy and Larry Zieske",
note = "Funding Information: Competing interests: B. Tucker Woodson is a consultant for Medtronic, Johnson & Johnson, Resmed, and Inspire Medical and has a device patent with Philips Respironics. Timothy Smith is a consultant for Intersect ENT and Entrigue and received a grant from the National Institutes of Health. Michael G. Stewart is on the medical advisory board of Merck. Funding Information: Funding source: This study was supported by the American Academy of Otolaryngology—Head & Neck Surgery Foundation. Dr Weaver was supported by a career development award (HL068849) from the National Heart, Lung, and Blood Institute. Funding Information: We acknowledge the study coordination by Tasha Carmon and preliminary statistical analyses by Robert Clare, PhD, both at the Duke Clinical Research Institute. This study was supported by the American Academy of Otolaryngology—Head & Neck Surgery Foundation. Dr Weaver was supported by a career development award (HL068849) from the National Heart, Lung, and Blood Institute. ",
year = "2011",
month = apr,
doi = "10.1177/0194599810394982",
language = "English (US)",
volume = "144",
pages = "623--631",
journal = "Otolaryngology - Head and Neck Surgery (United States)",
issn = "0194-5998",
publisher = "Mosby Inc.",
number = "4",
}