Study on the potential anti-cancer activity of phosphonium and ammonium-based ionic liquids

Vineet Kumar, Sanjay V. Malhotra

Research output: Contribution to journalArticlepeer-review

93 Scopus citations

Abstract

The anti-cancer activity and cytotoxicity of phosphonium and ammonium-based ionic liquids (ILs) have been determined for the first time via NCI's in vitro 60 human tumor cell lines. The preliminary SAR showed that the chain length of alkyl substitution on the cations plays crucial role towards anti-tumor activity and cytotoxicity of these ionic liquids. In general, phosphonium-based ILs were found to be more active and less cytotoxic as compared to ammonium ILs. Cell line data and hollow fiber study has demonstrated the potential of ILs to be developed as therapeutic agent.

Original languageEnglish (US)
Pages (from-to)4643-4646
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume19
Issue number16
DOIs
StatePublished - Aug 15 2009
Externally publishedYes

Keywords

  • Anti-cancer
  • Anti-tumor
  • Cytotoxicity
  • Ionic liquids

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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