Study on the potential anti-cancer activity of phosphonium and ammonium-based ionic liquids

Vineet Kumar; Sanjay V. Malhotra

doi:10.1016/j.bmcl.2009.06.086

Study on the potential anti-cancer activity of phosphonium and ammonium-based ionic liquids

Vineet Kumar, Sanjay V. Malhotra

Research output: Contribution to journal › Article › peer-review

122 Scopus citations

Abstract

The anti-cancer activity and cytotoxicity of phosphonium and ammonium-based ionic liquids (ILs) have been determined for the first time via NCI's in vitro 60 human tumor cell lines. The preliminary SAR showed that the chain length of alkyl substitution on the cations plays crucial role towards anti-tumor activity and cytotoxicity of these ionic liquids. In general, phosphonium-based ILs were found to be more active and less cytotoxic as compared to ammonium ILs. Cell line data and hollow fiber study has demonstrated the potential of ILs to be developed as therapeutic agent.

Original language	English (US)
Pages (from-to)	4643-4646
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	19
Issue number	16
DOIs	https://doi.org/10.1016/j.bmcl.2009.06.086
State	Published - Aug 15 2009
Externally published	Yes

Keywords

Anti-cancer
Anti-tumor
Cytotoxicity
Ionic liquids

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2009.06.086

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title = "Study on the potential anti-cancer activity of phosphonium and ammonium-based ionic liquids",

abstract = "The anti-cancer activity and cytotoxicity of phosphonium and ammonium-based ionic liquids (ILs) have been determined for the first time via NCI's in vitro 60 human tumor cell lines. The preliminary SAR showed that the chain length of alkyl substitution on the cations plays crucial role towards anti-tumor activity and cytotoxicity of these ionic liquids. In general, phosphonium-based ILs were found to be more active and less cytotoxic as compared to ammonium ILs. Cell line data and hollow fiber study has demonstrated the potential of ILs to be developed as therapeutic agent.",

keywords = "Anti-cancer, Anti-tumor, Cytotoxicity, Ionic liquids",

author = "Vineet Kumar and Malhotra, {Sanjay V.}",

note = "Funding Information: The authors would like to thank the NCI Developmental Therapeutics Program for 60 cell line screen of compounds described in this paper. This project has been funded in whole or in part with federal funds from the National Cancer Institute, National Institutes of Health, under Contract No. HHSN261200800001E. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. ",

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AU - Kumar, Vineet

AU - Malhotra, Sanjay V.

N1 - Funding Information: The authors would like to thank the NCI Developmental Therapeutics Program for 60 cell line screen of compounds described in this paper. This project has been funded in whole or in part with federal funds from the National Cancer Institute, National Institutes of Health, under Contract No. HHSN261200800001E. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government.

PY - 2009/8/15

Y1 - 2009/8/15

N2 - The anti-cancer activity and cytotoxicity of phosphonium and ammonium-based ionic liquids (ILs) have been determined for the first time via NCI's in vitro 60 human tumor cell lines. The preliminary SAR showed that the chain length of alkyl substitution on the cations plays crucial role towards anti-tumor activity and cytotoxicity of these ionic liquids. In general, phosphonium-based ILs were found to be more active and less cytotoxic as compared to ammonium ILs. Cell line data and hollow fiber study has demonstrated the potential of ILs to be developed as therapeutic agent.

AB - The anti-cancer activity and cytotoxicity of phosphonium and ammonium-based ionic liquids (ILs) have been determined for the first time via NCI's in vitro 60 human tumor cell lines. The preliminary SAR showed that the chain length of alkyl substitution on the cations plays crucial role towards anti-tumor activity and cytotoxicity of these ionic liquids. In general, phosphonium-based ILs were found to be more active and less cytotoxic as compared to ammonium ILs. Cell line data and hollow fiber study has demonstrated the potential of ILs to be developed as therapeutic agent.

KW - Anti-cancer

KW - Anti-tumor

KW - Cytotoxicity

KW - Ionic liquids

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Study on the potential anti-cancer activity of phosphonium and ammonium-based ionic liquids

Abstract

Keywords

ASJC Scopus subject areas

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