Study of dosimetric variation due to interfraction organ movement in high dose rate interstital (MUPIT) brachytherapy for gynecologic malignancies

Thanigaimalai Velmurugan, Prabakar Sukumar, Chokkalingam Krishnappan, Raghavendiran Boopathy

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Ten patients with cancer of uterine cervix who underwent interstitial brachytherapy using MUPIT templates were CT scanned (CT1) using which bladder, rectum and CTV were delineated. The treatment plan PCT1 was generated and optimized geometrically on the volume. CT scan (CT2) was repeated before the second fraction of the treatment CTV and critical organs were delineated. The plan (PCT2) was created by reproducing the Plan PCT1 in the CT2 images and compared with PCT1. Bladder, Rectum and CTV percentage volume variation ranges from +28.6% to-34.3%, 38.4% to-14.9% and 8.5% to-15.2% respectively. Maximum dose variation in bladder was +17.1%, in rectum was up to +410% and in CTV was-13.0%. The dose to these structures varies independently with no strong correlation with the volume variation. Hence it is suggested that repeat CT and re-planning is mandatory before second fraction execution.

Original languageEnglish (US)
Pages (from-to)85-95
Number of pages11
JournalPolish Journal of Medical Physics and Engineering
Volume16
Issue number2
DOIs
StatePublished - 2010
Externally publishedYes

Keywords

  • Inter-fraction dose variation
  • Interstitial brachytherapy
  • Mupit implant

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging

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