TY - JOUR
T1 - Study of dosimetric variation due to interfraction organ movement in high dose rate interstital (MUPIT) brachytherapy for gynecologic malignancies
AU - Velmurugan, Thanigaimalai
AU - Sukumar, Prabakar
AU - Krishnappan, Chokkalingam
AU - Boopathy, Raghavendiran
PY - 2010
Y1 - 2010
N2 - Ten patients with cancer of uterine cervix who underwent interstitial brachytherapy using MUPIT templates were CT scanned (CT1) using which bladder, rectum and CTV were delineated. The treatment plan PCT1 was generated and optimized geometrically on the volume. CT scan (CT2) was repeated before the second fraction of the treatment CTV and critical organs were delineated. The plan (PCT2) was created by reproducing the Plan PCT1 in the CT2 images and compared with PCT1. Bladder, Rectum and CTV percentage volume variation ranges from +28.6% to-34.3%, 38.4% to-14.9% and 8.5% to-15.2% respectively. Maximum dose variation in bladder was +17.1%, in rectum was up to +410% and in CTV was-13.0%. The dose to these structures varies independently with no strong correlation with the volume variation. Hence it is suggested that repeat CT and re-planning is mandatory before second fraction execution.
AB - Ten patients with cancer of uterine cervix who underwent interstitial brachytherapy using MUPIT templates were CT scanned (CT1) using which bladder, rectum and CTV were delineated. The treatment plan PCT1 was generated and optimized geometrically on the volume. CT scan (CT2) was repeated before the second fraction of the treatment CTV and critical organs were delineated. The plan (PCT2) was created by reproducing the Plan PCT1 in the CT2 images and compared with PCT1. Bladder, Rectum and CTV percentage volume variation ranges from +28.6% to-34.3%, 38.4% to-14.9% and 8.5% to-15.2% respectively. Maximum dose variation in bladder was +17.1%, in rectum was up to +410% and in CTV was-13.0%. The dose to these structures varies independently with no strong correlation with the volume variation. Hence it is suggested that repeat CT and re-planning is mandatory before second fraction execution.
KW - Inter-fraction dose variation
KW - Interstitial brachytherapy
KW - Mupit implant
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U2 - 10.2478/v10013-010-0008-6
DO - 10.2478/v10013-010-0008-6
M3 - Article
AN - SCOPUS:80052019694
SN - 1425-4689
VL - 16
SP - 85
EP - 95
JO - Polish Journal of Medical Physics and Engineering
JF - Polish Journal of Medical Physics and Engineering
IS - 2
ER -