Studies on the transfer of steroid hormones across the blood-cerebrospinal fluid barrier in the rhesus monkey

Samuel P. Marynick, Woodrow W. Havens, Michael H. Ebert, D. Lynn Loriaux, Sam Robertson

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Indwelling canulae were placed in the lateral ventricles of the brains of six adult male rhesus monkeys, and the movement of estradiol-17β (E2), testosterone (T), and 5α-dihydrotestosterone (DHT) across the blood-cerebrospinal fluid (CSF) barrier was measured. Serial samples of blood and CSF were collected every 30 minutes during a 6 hour infusion of the tritiated steroids, and the quantity of free steroid in the blood and CSF was determined by recrystallization to constant specific activity. During the course of the 6-hour infusion, the average CSF concentration of steroid, expressed as dpm/ml, was about 3.5% of the concurrent plasma level of E2, 1.6% of the concurrent plasma level of T, and 0.08% of the concurrent plasma level of DHT. It is proposed that these differences in steroid transfer can be attributed to differential binding of these steroids to testosterone-estrogen-binding globulin (TeBG) in plasma.

Original languageEnglish (US)
Pages (from-to)400-405
Number of pages6
JournalEndocrinology
Volume99
Issue number2
DOIs
StatePublished - Aug 1976

ASJC Scopus subject areas

  • Endocrinology

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