Studies on the role of sex steroids in the feedback control of gonadotropin concentrations in men. III. Androgen resistance in primary gonadal failure

S. J. Winters, R. J. Sherins, Donald (Lynn) Loriaux

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The negative feedback control of serum gonadotropins by sex steroids was studied in eight men with Leydig cell insufficiency, four of whom with unmeasurable Leydig cell function. Mean serum LH and FSH concentrations, the pattern of LH pulsatile release, and the response of gonadotropins to LRH stimulation were studied before and at the completion of 4-day continuous infusions of testosterone (T; 15 mg/day), 17β-estradiol (E; 90 μg/day), and 5α-dihydrotestosterone (DHT; 7.0 mg/day). Both T and E infusion resulted in approximately 30% suppression of mean serum LH and FSH concentrations in hypogonadal subjects; these responses were similar to those of normal men. Neither T nor E infusion produced a decrease in LH pulse frequency or amplitude in hypogonadal men. This differs from the decrease in LH pulse frequency seen with T and the fall in LH pulse amplitude during E infusion observed in normal men. The fall in mean serum LH concentration during infusion of the nonaromatizable andorgen DHT was significantly less in the hypogonadal (11 ± 2.7%) than in the normal men (35 ± 10%; P

Original languageEnglish (US)
Pages (from-to)553-558
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Issue number4
Publication statusPublished - 1979
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

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