Studies on the hypothalamic control of tsh secretion

A. Kajihara, J. W. Kendall

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Thyroidal radioiodine metabolism was examined after either radiofrequency lesions or implantation of thyroxine in agar into the anterior hypothalamus of hypophysectomized rats bearing multiple pituitary transplants under the kidney capsule. Bilateral lesions in the region of the paraventricular nuclei depressed 1311 uptake by the thyroid gland measured 24 h after lesioning. Thyroidal 1311 release was also depressed by such lesions. Similarly, thyroxine-in-agar pellets implanted bilaterally in the region of the paraventricular nuclei depressed 1311 uptake and release. It is concluded that the anterior hypothalamus participates in the regulation of TSH secretion from transplanted pituitaries.

Original languageEnglish (US)
Pages (from-to)53-63
Number of pages11
JournalNeuroendocrinology
Volume5
Issue number1-2
DOIs
StatePublished - Jan 1 1969

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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