Studies on the control of myelinogenesis. 3. Signalling of oligodendrocyte myelination by regenerating peripheral axons

E. L. Weinberg, Peter Spencer

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Continuing from earlier work which demonstrated the peripheral axonal regulation of Schwann cell myelination, this study has investigated the possibility that a peripheral axon can stimulate oligodendrocyte myelination. To test this hypothesis, regenerating PNS axons were allowed to interact with uncommitted oligodendrocytes by transecting a rat peroneal nerve and inserting a segment of the autologous optic nerve between the cut ends. Grafts were maintained for 4-28 weeks and then examined by light and electron microscopy. A few regenerating peripheral myelinated nerve fibers penetrated the optic nerve graft. Some axons penetrated the outer margin of the graft, were myelinated by Schwann cells, and surrounded by astrocyte processes bordered by basal lamina. More centrally in the optic nerve graft, regenerating peripheral axons displayed myelin of CNS type. The outer myelin lamella abutted directly on the plasmalemma surface of surrounding astrocytic processes and was expanded focally to form a glial tongue. These observations demonstrate the experimental induction of central myelination by regenerating peripheral axons and suggest the existence of a common neuronal mechanism to stimulate myelin formation by both the Schwann cell and the oligodendrocyte.

Original languageEnglish (US)
Pages (from-to)273-279
Number of pages7
JournalBrain Research
Volume162
Issue number2
DOIs
StatePublished - Feb 23 1979
Externally publishedYes

Fingerprint

Oligodendroglia
Axons
Schwann Cells
Optic Nerve
Myelin Sheath
Transplants
Myelinated Nerve Fibers
Peroneal Nerve
Peripheral Nerves
Tongue
Basement Membrane
Neuroglia
Astrocytes
Electron Microscopy
Light

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Studies on the control of myelinogenesis. 3. Signalling of oligodendrocyte myelination by regenerating peripheral axons. / Weinberg, E. L.; Spencer, Peter.

In: Brain Research, Vol. 162, No. 2, 23.02.1979, p. 273-279.

Research output: Contribution to journalArticle

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