Studies on memory: Inhibitors of protein synthesis also inhibit catecholamine synthesis

L. B. Flexner, R. H. Goodman

Research output: Contribution to journalArticle

69 Scopus citations

Abstract

The rates of accumulation of newly synthesized catecholamines and endogenous catecholamine levels in mice were determined after treatment with cycloheximide, acetoxycycloheximide, puromycin, and anisomycin. The rates of accumulation were found to be decreased by all antibiotics tested, weaking the assumption that their amnestic effects are due solely to inhibition of protein synthesis.

Original languageEnglish (US)
Pages (from-to)4660-4663
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume72
Issue number11
DOIs
StatePublished - 1975

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