Studies on memory: Inhibitors of protein synthesis also inhibit catecholamine synthesis

L. B. Flexner, Richard Goodman

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

The rates of accumulation of newly synthesized catecholamines and endogenous catecholamine levels in mice were determined after treatment with cycloheximide, acetoxycycloheximide, puromycin, and anisomycin. The rates of accumulation were found to be decreased by all antibiotics tested, weaking the assumption that their amnestic effects are due solely to inhibition of protein synthesis.

Original languageEnglish (US)
Pages (from-to)4660-4663
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume72
Issue number11
StatePublished - 1975
Externally publishedYes

Fingerprint

Protein Synthesis Inhibitors
Catecholamines
Anisomycin
Puromycin
Cycloheximide
Anti-Bacterial Agents
Proteins
acetoxycycloheximide
Inhibition (Psychology)

ASJC Scopus subject areas

  • General
  • Genetics

Cite this

@article{b7e8571acade4849b09c44fd2881e0bf,
title = "Studies on memory: Inhibitors of protein synthesis also inhibit catecholamine synthesis",
abstract = "The rates of accumulation of newly synthesized catecholamines and endogenous catecholamine levels in mice were determined after treatment with cycloheximide, acetoxycycloheximide, puromycin, and anisomycin. The rates of accumulation were found to be decreased by all antibiotics tested, weaking the assumption that their amnestic effects are due solely to inhibition of protein synthesis.",
author = "Flexner, {L. B.} and Richard Goodman",
year = "1975",
language = "English (US)",
volume = "72",
pages = "4660--4663",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
number = "11",

}

TY - JOUR

T1 - Studies on memory

T2 - Inhibitors of protein synthesis also inhibit catecholamine synthesis

AU - Flexner, L. B.

AU - Goodman, Richard

PY - 1975

Y1 - 1975

N2 - The rates of accumulation of newly synthesized catecholamines and endogenous catecholamine levels in mice were determined after treatment with cycloheximide, acetoxycycloheximide, puromycin, and anisomycin. The rates of accumulation were found to be decreased by all antibiotics tested, weaking the assumption that their amnestic effects are due solely to inhibition of protein synthesis.

AB - The rates of accumulation of newly synthesized catecholamines and endogenous catecholamine levels in mice were determined after treatment with cycloheximide, acetoxycycloheximide, puromycin, and anisomycin. The rates of accumulation were found to be decreased by all antibiotics tested, weaking the assumption that their amnestic effects are due solely to inhibition of protein synthesis.

UR - http://www.scopus.com/inward/record.url?scp=0016747723&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016747723&partnerID=8YFLogxK

M3 - Article

C2 - 1060144

AN - SCOPUS:0016747723

VL - 72

SP - 4660

EP - 4663

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 11

ER -