Studies of the role of sex steroids in the feedback control of FSH concentrations in men.

R. J. Sherins, Donald (Lynn) Loriaux

Research output: Contribution to journalArticle

121 Citations (Scopus)

Abstract

Studies on the role of sex steroids in the feedback control of follicle stimulating hormone (FSH) concentrations in 22-35 year old men are reported. 10 normal volunteers and 8 men undergoing evaluation for azoospermia or oligospermia received steroids by constant infusion for 96 hours at twice the estimated daily production rate of normal men to obtain stable levels in peripheral blood. 15 mg of testosterone increased plasma testosterone and estradiol levels 2-fold and suppressed FSH and luteinizing hormone (LH) approximately 40% during infusion Days 3 and 4. 90 mcg of estradiol/day caused similar suppression of FSH and LH and the addition of 4.5 mg of 17 alpha-hydroxyprogesterone had no additive effect. 7.5 mg of dihydrotestosterone/day produced no detectible changes in FSH or LH. No evidence for a selective effect of any of the steroids on FSH secretion was seen. These data support the concept that although there is a specific seminiferous tubular factor regulating FSH secretion, testicular steroids also modulate FSH secretion.

Original languageEnglish (US)
Pages (from-to)886-893
Number of pages8
JournalJournal of Clinical Endocrinology and Metabolism
Volume36
Issue number5
StatePublished - May 1973
Externally publishedYes

Fingerprint

Follicle Stimulating Hormone
Feedback control
Steroids
Luteinizing Hormone
Testosterone
Estradiol
17-alpha-Hydroxyprogesterone
Oligospermia
Azoospermia
Dihydrotestosterone
Healthy Volunteers
Blood
Plasmas

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Studies of the role of sex steroids in the feedback control of FSH concentrations in men. / Sherins, R. J.; Loriaux, Donald (Lynn).

In: Journal of Clinical Endocrinology and Metabolism, Vol. 36, No. 5, 05.1973, p. 886-893.

Research output: Contribution to journalArticle

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