Studies of human immunodeficiency virus type 1 mucosal viral shedding and transmission in Kenya

Julie Overbaugh; Joan Kreiss; Mary Poss; Paul Lewis; Sara Mostad; Grace John; Ruth Nduati; Dorothy Mbori-Ngacha; Harold Martin; Barbra Richardson; Stephanie Jackson; Joel Neilson; E. Michelle Long; Dana Panteleeff; Mary Welch; Joel Rakwar; Denis Jackson; Bhavna Chohan; Ludo Lavreys; Kishorchandra Mandaliya; Jeckoniah Ndinya-Achola; Job Bwayo

doi:10.1086/314792

Studies of human immunodeficiency virus type 1 mucosal viral shedding and transmission in Kenya

Julie Overbaugh, Joan Kreiss, Mary Poss, Paul Lewis, Sara Mostad, Grace John, Ruth Nduati, Dorothy Mbori-Ngacha, Harold Martin, Barbra Richardson, Stephanie Jackson, Joel Neilson, E. Michelle Long, Dana Panteleeff, Mary Welch, Joel Rakwar, Denis Jackson, Bhavna Chohan, Ludo Lavreys, Kishorchandra MandaliyaJeckoniah Ndinya-Achola, Job Bwayo

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

If human immunodeficiency virus type 1 (HIV-1) vaccines are to be highly effective, it is essential to understand the virologic factors that contribute to HIV-1 transmission. It is likely that transmission is determined, in part, by the genotype or phenotype (or both) of infectious virus present in the index case, which in turn will influence the quantity of virus that may be exchanged during sexual contact. Transmission may also depend on the fitness of the virus for replication in the exposed individual, which may be influenced by whether a virus encounters a target cell that is susceptible to infection by that specific variant. Of interest, our data suggest that the complexity of the virus that is transmitted may be different in female and male sexual exposures.

Original language	English (US)
Pages (from-to)	S401-S404
Journal	Journal of Infectious Diseases
Volume	179
Issue number	SUPPL. 3
DOIs	https://doi.org/10.1086/314792
State	Published - 1999
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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10.1086/314792

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Overbaugh, J., Kreiss, J., Poss, M., Lewis, P., Mostad, S., John, G., Nduati, R., Mbori-Ngacha, D., Martin, H., Richardson, B., Jackson, S., Neilson, J., Long, E. M., Panteleeff, D., Welch, M., Rakwar, J., Jackson, D., Chohan, B., Lavreys, L., ... Bwayo, J. (1999). Studies of human immunodeficiency virus type 1 mucosal viral shedding and transmission in Kenya. Journal of Infectious Diseases, 179(SUPPL. 3), S401-S404. https://doi.org/10.1086/314792

Overbaugh, J, Kreiss, J, Poss, M, Lewis, P, Mostad, S, John, G, Nduati, R, Mbori-Ngacha, D, Martin, H, Richardson, B, Jackson, S, Neilson, J, Long, EM, Panteleeff, D, Welch, M, Rakwar, J, Jackson, D, Chohan, B, Lavreys, L, Mandaliya, K, Ndinya-Achola, J & Bwayo, J 1999, 'Studies of human immunodeficiency virus type 1 mucosal viral shedding and transmission in Kenya', Journal of Infectious Diseases, vol. 179, no. SUPPL. 3, pp. S401-S404. https://doi.org/10.1086/314792

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abstract = "If human immunodeficiency virus type 1 (HIV-1) vaccines are to be highly effective, it is essential to understand the virologic factors that contribute to HIV-1 transmission. It is likely that transmission is determined, in part, by the genotype or phenotype (or both) of infectious virus present in the index case, which in turn will influence the quantity of virus that may be exchanged during sexual contact. Transmission may also depend on the fitness of the virus for replication in the exposed individual, which may be influenced by whether a virus encounters a target cell that is susceptible to infection by that specific variant. Of interest, our data suggest that the complexity of the virus that is transmitted may be different in female and male sexual exposures.",

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AU - Martin, Harold

AU - Richardson, Barbra

AU - Jackson, Stephanie

AU - Neilson, Joel

AU - Long, E. Michelle

AU - Panteleeff, Dana

AU - Welch, Mary

AU - Rakwar, Joel

AU - Jackson, Denis

AU - Chohan, Bhavna

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Studies of human immunodeficiency virus type 1 mucosal viral shedding and transmission in Kenya

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