Studies of human immunodeficiency virus type 1 mucosal viral shedding and transmission in Kenya

Julie Overbaugh, Joan Kreiss, Mary Poss, Paul Lewis, Sara Mostad, Grace John, Ruth Nduati, Dorothy Mbori-Ngacha, Harold Martin, Barbra Richardson, Stephanie Jackson, Joel Neilson, E. Michelle Long, Dana Panteleeff, Mary Welch, Joel Rakwar, Denis Jackson, Bhavna Chohan, Ludo Lavreys, Kishorchandra MandaliyaJeckoniah Ndinya-Achola, Job Bwayo

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

If human immunodeficiency virus type 1 (HIV-1) vaccines are to be highly effective, it is essential to understand the virologic factors that contribute to HIV-1 transmission. It is likely that transmission is determined, in part, by the genotype or phenotype (or both) of infectious virus present in the index case, which in turn will influence the quantity of virus that may be exchanged during sexual contact. Transmission may also depend on the fitness of the virus for replication in the exposed individual, which may be influenced by whether a virus encounters a target cell that is susceptible to infection by that specific variant. Of interest, our data suggest that the complexity of the virus that is transmitted may be different in female and male sexual exposures.

Original languageEnglish (US)
Pages (from-to)S401-S404
JournalJournal of Infectious Diseases
Volume179
Issue numberSUPPL. 3
DOIs
StatePublished - 1999

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Studies of human immunodeficiency virus type 1 mucosal viral shedding and transmission in Kenya'. Together they form a unique fingerprint.

  • Cite this

    Overbaugh, J., Kreiss, J., Poss, M., Lewis, P., Mostad, S., John, G., Nduati, R., Mbori-Ngacha, D., Martin, H., Richardson, B., Jackson, S., Neilson, J., Long, E. M., Panteleeff, D., Welch, M., Rakwar, J., Jackson, D., Chohan, B., Lavreys, L., ... Bwayo, J. (1999). Studies of human immunodeficiency virus type 1 mucosal viral shedding and transmission in Kenya. Journal of Infectious Diseases, 179(SUPPL. 3), S401-S404. https://doi.org/10.1086/314792