Structure of the Cardiac Sodium Channel

Daohua Jiang, Hui Shi, Lige Tonggu, Tamer M. Gamal El-Din, Michael J. Lenaeus, Yan Zhao, Craig Yoshioka, Ning Zheng, William A. Catterall

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

The high-resolution structure of the cardiac sodium channel gives detailed insights into voltage-dependent activation, ion selectivity, arrhythmia mechanisms, and antiarrhythmic drug action at the atomic level.

Original languageEnglish (US)
Pages (from-to)122-134.e10
JournalCell
Volume180
Issue number1
DOIs
StatePublished - Jan 9 2020

Keywords

  • antiarrhytymic drugs
  • cryoelectron microscopy arrhythmia
  • fast inactivation
  • gating pore current
  • heart
  • sodium channel
  • sodium selectivity

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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