@article{d18e08b879144edd8f397ef99e29ca82,
title = "Structure of the Cardiac Sodium Channel",
abstract = "The high-resolution structure of the cardiac sodium channel gives detailed insights into voltage-dependent activation, ion selectivity, arrhythmia mechanisms, and antiarrhythmic drug action at the atomic level.",
keywords = "antiarrhytymic drugs, cryoelectron microscopy arrhythmia, fast inactivation, gating pore current, heart, sodium channel, sodium selectivity",
author = "Daohua Jiang and Hui Shi and Lige Tonggu and {Gamal El-Din}, {Tamer M.} and Lenaeus, {Michael J.} and Yan Zhao and Craig Yoshioka and Ning Zheng and Catterall, {William A.}",
note = "Funding Information: We are grateful to Dr. Eric Gouaux (Vollum Institute, Oregon Health & Science University) and the staff at the Cryo-EM Facility of Oregon Health & Science University for their advice and help in the early phase of this work. We thank J.D. Quispe of the University of Washington Cryo-EM Facility for advice and technical assistance during the main phase of data collection and Dr. Jin Li, Department of Pharmacology, University of Washington, for technical and editorial support. This research was supported by the NIH (R01 HL112808 to W.A.C. and N.Z.) and by the Howard Hughes Medical Institute (N.Z.). D.J. T.M.G.E.-D. M.J.L. N.Z. and W.A.C. designed the experiments. D.J. H.S. L.T. T.M.G.E.-D. C.Y. and Y.Z. carried out the experiments. D.J. N.Z. and W.A.C. wrote the paper. All authors analyzed and interpreted the results and reviewed and revised the paper. The authors declare no competing interests. Funding Information: We are grateful to Dr. Eric Gouaux (Vollum Institute, Oregon Health & Science University) and the staff at the Cryo-EM Facility of Oregon Health & Science University for their advice and help in the early phase of this work. We thank J.D. Quispe of the University of Washington Cryo-EM Facility for advice and technical assistance during the main phase of data collection and Dr. Jin Li, Department of Pharmacology, University of Washington, for technical and editorial support. This research was supported by the NIH ( R01 HL112808 to W.A.C. and N.Z.) and by the Howard Hughes Medical Institute (N.Z.). Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",
year = "2020",
month = jan,
day = "9",
doi = "10.1016/j.cell.2019.11.041",
language = "English (US)",
volume = "180",
pages = "122--134.e10",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "1",
}