Structure-function relationships in Src family and related protein tyrosine kinases

Giulio Superti-Furga, Sara Courtneidge

Research output: Contribution to journalArticle

169 Citations (Scopus)

Abstract

There is increasing evidence to suggest that cytoplasmic tyrosine kinases of the Src family have a pivotal role in the regulation of a number of cellular processes. Members of this family have been implicated in cellular responses to a variety of extracellular signals, such as those arising from growth factors and cell-cell interactions, as well as in differentiative and developmental processes in both vertebrates and invertebrates. A better understanding of the regulation and of the structure-function relationships of these enzymes might aid in the development of specific ways to interfere with their action, as well as serving as a paradigm for regulation of other protein tyrosine kinases that have SH2 and SH3 domains. In this review we will first discuss the regulation of Src family protein tyrosine kinases, with particular emphasis on their SH2 and SH3 domains. We will then briefly review other non-receptor protein tyrosine kinases that have SH2 and SH3 domains.

Original languageEnglish (US)
Pages (from-to)321-330
Number of pages10
JournalBioEssays
Volume17
Issue number4
StatePublished - 1995
Externally publishedYes

Fingerprint

protein-tyrosine kinases
src Homology Domains
structure-activity relationships
Protein-Tyrosine Kinases
src-Family Kinases
development aid
growth factors
tyrosine
Intercellular Signaling Peptides and Proteins
phosphotransferases (kinases)
invertebrates
vertebrates
cells
Enzymes
Invertebrates
enzymes
Cell Communication
Vertebrates

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Biochemistry
  • Cell Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Agricultural and Biological Sciences (miscellaneous)
  • Plant Science

Cite this

Structure-function relationships in Src family and related protein tyrosine kinases. / Superti-Furga, Giulio; Courtneidge, Sara.

In: BioEssays, Vol. 17, No. 4, 1995, p. 321-330.

Research output: Contribution to journalArticle

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