Structure, Function, and Regulation of the Corpus Luteum

Richard L. Stouffer, Jon D. Hennebold

    Research output: Chapter in Book/Report/Conference proceedingChapter

    31 Scopus citations


    The corpus luteum is a transient endocrine gland in the adult ovary that differentiates from the follicle wall after ovulation. It is vital to mammalian reproduction as it produces the steroid hormone, progesterone, which acts on the reproductive tract to permit embryo implantation and to support a maternal environment that sustains intrauterine pregnancy. This chapter will review the remarkable species differences in endocrine and local control of the development (luteinization), functional lifespan, and regression (luteolysis) of the corpus luteum. The review will focus on luteotropic and luteolytic factors that regulate the structure and function of the corpus luteum during the ovarian cycle, and in some species extend the luteal lifespan if pregnancy occurs.

    Original languageEnglish (US)
    Title of host publicationKnobil and Neill's Physiology of Reproduction
    Subtitle of host publicationTwo-Volume Set
    PublisherElsevier Inc.
    Number of pages54
    ISBN (Electronic)9780123977694
    ISBN (Print)9780123971753
    StatePublished - Jan 1 2015


    • Angiogenesis
    • Chorionic gonadotropin
    • Luteinization
    • Luteinizing hormone
    • Luteolysis
    • Maternal recognition of pregnancy
    • Progesterone
    • Prolactin
    • Prostaglandin Fα
    • Relaxin
    • Vascular endothelial growth factor

    ASJC Scopus subject areas

    • Medicine(all)


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