Structure, evolution, expression and regulation of insulin-like growth factors i and II

Peter Rotwein

    Research output: Contribution to journalReview articlepeer-review

    231 Scopus citations

    Abstract

    Insulin-like growth factors (IGF) I and II are chemically-related single-chain peptides with diverse actions on cellular growth and metabolism. This review will focus on recent information pertinent to the biochemical and molecular biological aspects of these peptides. Three areas will be examined: The structure of the two IGF molecules and their precursors will be analyzed; the complicated anatomy of the IGF genes and their mRNAs will be described; and the multiple ways in which the expression of IGF-I and IGF-II can be regulated will be discussed. Gaps in our understanding of these peptides will be highlighted in the context of opportunities for further investigation in this field.

    Original languageEnglish (US)
    Pages (from-to)3-18
    Number of pages16
    JournalGrowth Factors
    Volume5
    Issue number1
    DOIs
    StatePublished - 1991

    ASJC Scopus subject areas

    • Endocrinology
    • Clinical Biochemistry
    • Cell Biology

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