Structure, evolution, expression and regulation of insulin-like growth factors i and II

Peter Rotwein

doi:10.3109/08977199109000267

Structure, evolution, expression and regulation of insulin-like growth factors i and II

Peter Rotwein

Research output: Contribution to journal › Review article › peer-review

247 Scopus citations

Abstract

Insulin-like growth factors (IGF) I and II are chemically-related single-chain peptides with diverse actions on cellular growth and metabolism. This review will focus on recent information pertinent to the biochemical and molecular biological aspects of these peptides. Three areas will be examined: The structure of the two IGF molecules and their precursors will be analyzed; the complicated anatomy of the IGF genes and their mRNAs will be described; and the multiple ways in which the expression of IGF-I and IGF-II can be regulated will be discussed. Gaps in our understanding of these peptides will be highlighted in the context of opportunities for further investigation in this field.

Original language	English (US)
Pages (from-to)	3-18
Number of pages	16
Journal	Growth Factors
Volume	5
Issue number	1
DOIs	https://doi.org/10.3109/08977199109000267
State	Published - 1991
Externally published	Yes

ASJC Scopus subject areas

Endocrinology
Clinical Biochemistry
Cell Biology

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10.3109/08977199109000267

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title = "Structure, evolution, expression and regulation of insulin-like growth factors i and II",

abstract = "Insulin-like growth factors (IGF) I and II are chemically-related single-chain peptides with diverse actions on cellular growth and metabolism. This review will focus on recent information pertinent to the biochemical and molecular biological aspects of these peptides. Three areas will be examined: The structure of the two IGF molecules and their precursors will be analyzed; the complicated anatomy of the IGF genes and their mRNAs will be described; and the multiple ways in which the expression of IGF-I and IGF-II can be regulated will be discussed. Gaps in our understanding of these peptides will be highlighted in the context of opportunities for further investigation in this field.",

author = "Peter Rotwein",

note = "Funding Information: The studies from my laboratory cited in this manuscript were supported by NIH Grants HD20805, DK37449, and DK42748, and by Basic Research Grant #1-1223 from the March of Dimes Birth Defects Foundation. I am grateful to Dr William H. Daughaday for his insightful comments on the text, and appreciate the assistance of Janet Seavitte in typing the manuscript.",

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N2 - Insulin-like growth factors (IGF) I and II are chemically-related single-chain peptides with diverse actions on cellular growth and metabolism. This review will focus on recent information pertinent to the biochemical and molecular biological aspects of these peptides. Three areas will be examined: The structure of the two IGF molecules and their precursors will be analyzed; the complicated anatomy of the IGF genes and their mRNAs will be described; and the multiple ways in which the expression of IGF-I and IGF-II can be regulated will be discussed. Gaps in our understanding of these peptides will be highlighted in the context of opportunities for further investigation in this field.

AB - Insulin-like growth factors (IGF) I and II are chemically-related single-chain peptides with diverse actions on cellular growth and metabolism. This review will focus on recent information pertinent to the biochemical and molecular biological aspects of these peptides. Three areas will be examined: The structure of the two IGF molecules and their precursors will be analyzed; the complicated anatomy of the IGF genes and their mRNAs will be described; and the multiple ways in which the expression of IGF-I and IGF-II can be regulated will be discussed. Gaps in our understanding of these peptides will be highlighted in the context of opportunities for further investigation in this field.

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Structure, evolution, expression and regulation of insulin-like growth factors i and II

Abstract

ASJC Scopus subject areas

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