TY - JOUR
T1 - Structure and mechanism of AMPA receptor — auxiliary protein complexes
AU - Chen, Shanshuang
AU - Gouaux, Eric
N1 - Funding Information:
We thank H. Owen for help with manuscript preparation. This work was supported by the NIH under award number R01 NS038631, and E.G. is an investigator with the Howard Hughes Medical Institute.
Funding Information:
We thank H. Owen for help with manuscript preparation. This work was supported by the NIH under award number R01 NS038631 , and E.G. is an investigator with the Howard Hughes Medical Institute.
Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2019/2
Y1 - 2019/2
N2 - Ionotropic glutamate receptors in vertebrates are composed of three major subtypes – AMPA, kainate, and NMDA receptors – and mediate the majority of fast excitatory neurotransmission at chemical synapses of the central nervous system. Among the three major families, native AMPA receptors function as complexes with a variety of auxiliary subunits, which in turn modulate receptor trafficking, gating, pharmacology, and permeation. Despite the long history of structure-mechanism studies using soluble receptor domains or intact yet isolated receptors, structures of AMPA receptor-auxiliary subunit complexes have not been available until recent breakthroughs in single-particle cryo-electron microscopy. Single particle cryo-EM studies have, in turn, provided new insights into the structure and organization of AMPA receptor — auxiliary protein complexes and into the molecular mechanisms of AMPA receptor activation and desensitization.
AB - Ionotropic glutamate receptors in vertebrates are composed of three major subtypes – AMPA, kainate, and NMDA receptors – and mediate the majority of fast excitatory neurotransmission at chemical synapses of the central nervous system. Among the three major families, native AMPA receptors function as complexes with a variety of auxiliary subunits, which in turn modulate receptor trafficking, gating, pharmacology, and permeation. Despite the long history of structure-mechanism studies using soluble receptor domains or intact yet isolated receptors, structures of AMPA receptor-auxiliary subunit complexes have not been available until recent breakthroughs in single-particle cryo-electron microscopy. Single particle cryo-EM studies have, in turn, provided new insights into the structure and organization of AMPA receptor — auxiliary protein complexes and into the molecular mechanisms of AMPA receptor activation and desensitization.
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U2 - 10.1016/j.sbi.2019.01.011
DO - 10.1016/j.sbi.2019.01.011
M3 - Review article
C2 - 30825796
AN - SCOPUS:85062023623
VL - 54
SP - 104
EP - 111
JO - Current Opinion in Structural Biology
JF - Current Opinion in Structural Biology
SN - 0959-440X
ER -