Structural studies of copper(I) complexes of amyloid-β peptide fragments

Formation of two-coordinate bis(histidine) complexes

Richard A. Himes, Ga Young Park, Gnana Sutha Siluvai, Ninian Blackburn, Kenneth D. Karlin

Research output: Contribution to journalArticle

104 Citations (Scopus)

Abstract

(Chemical Equation Presented) The beta bind: Copper(I) binds to amyloid β-peptide fragments (see structure) as a stable bis(histidine), two-coordinate, near-linear complex, even in the presence of potential additional ligands. As has been proposed or assumed in other studies, the copper(I)-peptide complexes react with dioxygen to form the reactive oxygen species H2O2, without the need for a third histidine ligand to promote the chemistry.

Original languageEnglish (US)
Pages (from-to)9084-9087
Number of pages4
JournalAngewandte Chemie - International Edition
Volume47
Issue number47
DOIs
StatePublished - Nov 10 2008

Fingerprint

Peptide Fragments
Histidine
Amyloid
Peptides
Copper
Ligands
Reactive Oxygen Species
Oxygen

Keywords

  • Amyloids
  • Copper
  • EXAFS spectroscopy
  • Hydrogen peroxide
  • Reactive species

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

Cite this

Structural studies of copper(I) complexes of amyloid-β peptide fragments : Formation of two-coordinate bis(histidine) complexes. / Himes, Richard A.; Park, Ga Young; Siluvai, Gnana Sutha; Blackburn, Ninian; Karlin, Kenneth D.

In: Angewandte Chemie - International Edition, Vol. 47, No. 47, 10.11.2008, p. 9084-9087.

Research output: Contribution to journalArticle

Himes, Richard A. ; Park, Ga Young ; Siluvai, Gnana Sutha ; Blackburn, Ninian ; Karlin, Kenneth D. / Structural studies of copper(I) complexes of amyloid-β peptide fragments : Formation of two-coordinate bis(histidine) complexes. In: Angewandte Chemie - International Edition. 2008 ; Vol. 47, No. 47. pp. 9084-9087.
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