Structural studies of copper(I) complexes of amyloid-β peptide fragments: Formation of two-coordinate bis(histidine) complexes

Richard A. Himes, Ga Young Park, Gnana Sutha Siluvai, Ninian J. Blackburn, Kenneth D. Karlin

Research output: Contribution to journalArticle

108 Scopus citations

Abstract

(Chemical Equation Presented) The beta bind: Copper(I) binds to amyloid β-peptide fragments (see structure) as a stable bis(histidine), two-coordinate, near-linear complex, even in the presence of potential additional ligands. As has been proposed or assumed in other studies, the copper(I)-peptide complexes react with dioxygen to form the reactive oxygen species H2O2, without the need for a third histidine ligand to promote the chemistry.

Original languageEnglish (US)
Pages (from-to)9084-9087
Number of pages4
JournalAngewandte Chemie - International Edition
Volume47
Issue number47
DOIs
StatePublished - Nov 10 2008

Keywords

  • Amyloids
  • Copper
  • EXAFS spectroscopy
  • Hydrogen peroxide
  • Reactive species

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Fingerprint Dive into the research topics of 'Structural studies of copper(I) complexes of amyloid-β peptide fragments: Formation of two-coordinate bis(histidine) complexes'. Together they form a unique fingerprint.

  • Cite this