Structural studies of copper(I) complexes of amyloid-β peptide fragments: Formation of two-coordinate bis(histidine) complexes

Richard A. Himes, Ga Young Park, Gnana Sutha Siluvai, Ninian J. Blackburn, Kenneth D. Karlin

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(Chemical Equation Presented) The beta bind: Copper(I) binds to amyloid β-peptide fragments (see structure) as a stable bis(histidine), two-coordinate, near-linear complex, even in the presence of potential additional ligands. As has been proposed or assumed in other studies, the copper(I)-peptide complexes react with dioxygen to form the reactive oxygen species H2O2, without the need for a third histidine ligand to promote the chemistry.

Original languageEnglish (US)
Pages (from-to)9084-9087
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number47
StatePublished - Nov 10 2008



  • Amyloids
  • Copper
  • EXAFS spectroscopy
  • Hydrogen peroxide
  • Reactive species

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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