Structural studies of copper(I) complexes of amyloid-β peptide fragments: Formation of two-coordinate bis(histidine) complexes

Richard A. Himes; Ga Young Park; Gnana Sutha Siluvai; Ninian J. Blackburn; Kenneth D. Karlin

doi:10.1002/anie.200803908

Structural studies of copper(I) complexes of amyloid-β peptide fragments: Formation of two-coordinate bis(histidine) complexes

Richard A. Himes, Ga Young Park, Gnana Sutha Siluvai, Ninian J. Blackburn, Kenneth D. Karlin

Chemical Physiology and Biochemistry

Research output: Contribution to journal › Article › peer-review

131 Scopus citations

Abstract

(Chemical Equation Presented) The beta bind: Copper(I) binds to amyloid β-peptide fragments (see structure) as a stable bis(histidine), two-coordinate, near-linear complex, even in the presence of potential additional ligands. As has been proposed or assumed in other studies, the copper(I)-peptide complexes react with dioxygen to form the reactive oxygen species H₂O₂, without the need for a third histidine ligand to promote the chemistry.

Original language	English (US)
Pages (from-to)	9084-9087
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	47
Issue number	47
DOIs	https://doi.org/10.1002/anie.200803908
State	Published - Nov 10 2008

Keywords

Amyloids
Copper
EXAFS spectroscopy
Hydrogen peroxide
Reactive species

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.200803908

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abstract = "(Chemical Equation Presented) The beta bind: Copper(I) binds to amyloid β-peptide fragments (see structure) as a stable bis(histidine), two-coordinate, near-linear complex, even in the presence of potential additional ligands. As has been proposed or assumed in other studies, the copper(I)-peptide complexes react with dioxygen to form the reactive oxygen species H2O2, without the need for a third histidine ligand to promote the chemistry.",

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AU - Park, Ga Young

AU - Siluvai, Gnana Sutha

AU - Blackburn, Ninian J.

AU - Karlin, Kenneth D.

PY - 2008/11/10

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AB - (Chemical Equation Presented) The beta bind: Copper(I) binds to amyloid β-peptide fragments (see structure) as a stable bis(histidine), two-coordinate, near-linear complex, even in the presence of potential additional ligands. As has been proposed or assumed in other studies, the copper(I)-peptide complexes react with dioxygen to form the reactive oxygen species H2O2, without the need for a third histidine ligand to promote the chemistry.

KW - Amyloids

KW - Copper

KW - EXAFS spectroscopy

KW - Hydrogen peroxide

KW - Reactive species

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Structural studies of copper(I) complexes of amyloid-β peptide fragments: Formation of two-coordinate bis(histidine) complexes

Abstract

Keywords

ASJC Scopus subject areas

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