Structural modulation of dendritic spines during synaptic plasticity

Dale A. Fortin, Taasin Srivastava, Thomas Soderling

    Research output: Contribution to journalArticle

    59 Citations (Scopus)

    Abstract

    The majority of excitatory synaptic input in the brain is received by small bulbous actin-rich protrusions residing on the dendrites of glutamatergic neurons. These dendritic spines are the major sites of information processing in the brain. This conclusion is reinforced by the observation that many higher cognitive disorders, such as mental retardation, Rett syndrome, and autism, are associated with aberrant spine morphology. Mechanisms that regulate the maturation and plasticity of dendritic spines are therefore fundamental to understanding higher brain functions including learning and memory. It is well known that activity-driven changes in synaptic efficacy modulate spine morphology due to alterations in the underlying actin cytoskeleton. Recent studies have elucidated numerous molecular regulators that directly alter actin dynamics within dendritic spines. This review will emphasize activity-dependent changes in spine morphology and highlight likely roles of these actin-binding proteins.

    Original languageEnglish (US)
    Pages (from-to)326-341
    Number of pages16
    JournalNeuroscientist
    Volume18
    Issue number4
    DOIs
    StatePublished - Aug 2012

    Fingerprint

    Dendritic Spines
    Neuronal Plasticity
    Spine
    Actins
    Brain
    Rett Syndrome
    Microfilament Proteins
    Autistic Disorder
    Dendrites
    Actin Cytoskeleton
    Automatic Data Processing
    Intellectual Disability
    Learning
    Neurons

    Keywords

    • actin
    • dendrite
    • LTP
    • microRNA
    • spine
    • translation

    ASJC Scopus subject areas

    • Neuroscience(all)
    • Clinical Neurology

    Cite this

    Structural modulation of dendritic spines during synaptic plasticity. / Fortin, Dale A.; Srivastava, Taasin; Soderling, Thomas.

    In: Neuroscientist, Vol. 18, No. 4, 08.2012, p. 326-341.

    Research output: Contribution to journalArticle

    Fortin, DA, Srivastava, T & Soderling, T 2012, 'Structural modulation of dendritic spines during synaptic plasticity', Neuroscientist, vol. 18, no. 4, pp. 326-341. https://doi.org/10.1177/1073858411407206
    Fortin, Dale A. ; Srivastava, Taasin ; Soderling, Thomas. / Structural modulation of dendritic spines during synaptic plasticity. In: Neuroscientist. 2012 ; Vol. 18, No. 4. pp. 326-341.
    @article{ead428e2f3f14027bc02f46d29bbb6af,
    title = "Structural modulation of dendritic spines during synaptic plasticity",
    abstract = "The majority of excitatory synaptic input in the brain is received by small bulbous actin-rich protrusions residing on the dendrites of glutamatergic neurons. These dendritic spines are the major sites of information processing in the brain. This conclusion is reinforced by the observation that many higher cognitive disorders, such as mental retardation, Rett syndrome, and autism, are associated with aberrant spine morphology. Mechanisms that regulate the maturation and plasticity of dendritic spines are therefore fundamental to understanding higher brain functions including learning and memory. It is well known that activity-driven changes in synaptic efficacy modulate spine morphology due to alterations in the underlying actin cytoskeleton. Recent studies have elucidated numerous molecular regulators that directly alter actin dynamics within dendritic spines. This review will emphasize activity-dependent changes in spine morphology and highlight likely roles of these actin-binding proteins.",
    keywords = "actin, dendrite, LTP, microRNA, spine, translation",
    author = "Fortin, {Dale A.} and Taasin Srivastava and Thomas Soderling",
    year = "2012",
    month = "8",
    doi = "10.1177/1073858411407206",
    language = "English (US)",
    volume = "18",
    pages = "326--341",
    journal = "Neuroscientist",
    issn = "1073-8584",
    publisher = "SAGE Publications Inc.",
    number = "4",

    }

    TY - JOUR

    T1 - Structural modulation of dendritic spines during synaptic plasticity

    AU - Fortin, Dale A.

    AU - Srivastava, Taasin

    AU - Soderling, Thomas

    PY - 2012/8

    Y1 - 2012/8

    N2 - The majority of excitatory synaptic input in the brain is received by small bulbous actin-rich protrusions residing on the dendrites of glutamatergic neurons. These dendritic spines are the major sites of information processing in the brain. This conclusion is reinforced by the observation that many higher cognitive disorders, such as mental retardation, Rett syndrome, and autism, are associated with aberrant spine morphology. Mechanisms that regulate the maturation and plasticity of dendritic spines are therefore fundamental to understanding higher brain functions including learning and memory. It is well known that activity-driven changes in synaptic efficacy modulate spine morphology due to alterations in the underlying actin cytoskeleton. Recent studies have elucidated numerous molecular regulators that directly alter actin dynamics within dendritic spines. This review will emphasize activity-dependent changes in spine morphology and highlight likely roles of these actin-binding proteins.

    AB - The majority of excitatory synaptic input in the brain is received by small bulbous actin-rich protrusions residing on the dendrites of glutamatergic neurons. These dendritic spines are the major sites of information processing in the brain. This conclusion is reinforced by the observation that many higher cognitive disorders, such as mental retardation, Rett syndrome, and autism, are associated with aberrant spine morphology. Mechanisms that regulate the maturation and plasticity of dendritic spines are therefore fundamental to understanding higher brain functions including learning and memory. It is well known that activity-driven changes in synaptic efficacy modulate spine morphology due to alterations in the underlying actin cytoskeleton. Recent studies have elucidated numerous molecular regulators that directly alter actin dynamics within dendritic spines. This review will emphasize activity-dependent changes in spine morphology and highlight likely roles of these actin-binding proteins.

    KW - actin

    KW - dendrite

    KW - LTP

    KW - microRNA

    KW - spine

    KW - translation

    UR - http://www.scopus.com/inward/record.url?scp=84864343109&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=84864343109&partnerID=8YFLogxK

    U2 - 10.1177/1073858411407206

    DO - 10.1177/1073858411407206

    M3 - Article

    VL - 18

    SP - 326

    EP - 341

    JO - Neuroscientist

    JF - Neuroscientist

    SN - 1073-8584

    IS - 4

    ER -