Structural modifications of nucleosides in ionic liquids

Vineet Kumar, Virinder S. Parmar, Sanjay V. Malhotra

Research output: Contribution to journalShort surveypeer-review

15 Scopus citations

Abstract

Nucleoside chemistry represents an important research area for drug discovery, as many nucleoside analogs are prominent drugs and have been widely applied for cancer and viral chemotherapy. However, the synthesis of modified nucleosides presents a major challenge, which is further aggravated by poor solubility of these compounds in common organic solvents. Most of the currently available methods for nucleoside modification employ toxic high boiling solvents; require long reaction time and tedious workup methods. As such, there is constant effort to develop process chemistry in alternative medium to limit the use of organic solvents that are hazardous to the environment and can be deleterious to human health. One such approach is to use ionic liquids, which are 'designer materials' with unique and tunable physico-chemical properties. Studies have shown that methodologies using ionic liquids are highly efficient and convenient for the synthesis of nucleoside analogs, as demonstrated by the preparation of pharmaceutically important anti-viral drugs. This article summarizes recent efforts on nucleoside modification using ionic liquids.

Original languageEnglish (US)
Pages (from-to)1260-1265
Number of pages6
JournalBiochimie
Volume92
Issue number9
DOIs
StatePublished - Sep 2010
Externally publishedYes

Keywords

  • Anti-viral drugs
  • Ionic liquids
  • Nucleosides
  • Solubility

ASJC Scopus subject areas

  • Biochemistry

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