Structural mechanisms of inflammasome regulation revealed by cryo-EM studies

Jianhao Cao, Grady Nash, Liman Zhang

Research output: Contribution to journalReview articlepeer-review

Abstract

Inflammasomes are cytosolic protein complexes that form in response to pathogen or damage signals and initiate inflammation. Signal transduction in the inflammasome pathway occurs via protein–protein interaction, protein conformational change, and oligomerization. Recent advances in structural biology have provided multiple insights in inflammasome regulation that are both biologically intriguing and therapeutically valuable. In this review, we summarize the current understanding of three most studied inflammasome complexes: the NAIP/NLRC4, NLRP1, and NLRP3 inflammasomes. We discuss the general mechanisms and unique features of their regulation and how investigating these systems may contribute to therapeutic applications.

Original languageEnglish (US)
Article number102390
JournalCurrent Opinion in Structural Biology
Volume75
DOIs
StatePublished - Aug 2022
Externally publishedYes

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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