Structural correlates of the creatine transporter function regulation: the undiscovered country

Lucia Santacruz, Danny Jacobs

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

Creatine (Cr) and phosphocreatine constitute an energy shuttle that links ATP production in mitochondria to subcellular locations of ATP consumption. Cells in tissues that are reliant on this energy shuttle, such as myocytes and neurons, appear to have very limited ability to synthesize creatine. Therefore, these cells depend on Cr uptake across the cell membrane by a specialized creatine transporter (CrT solute carrier SLC6A8) in order to maintain intracellular creatine levels. Cr supplementation has been shown to have a beneficial effect in numerous in vitro and in vivo models, particularly in cases of oxidative stress, and is also widely used by athletes as a performance enhancement nutraceutical. Intracellular creatine content is maintained within narrow limits. However, the physiological and cellular mechanisms that mediate Cr transport during health and disease (such as cardiac failure) are not understood. In this narrative mini-review, we summarize the last three decades of research on CrT structure, function and regulation.

Original languageEnglish (US)
Pages (from-to)2049-2055
Number of pages7
JournalAmino Acids
Volume48
Issue number8
DOIs
StatePublished - Aug 1 2016
Externally publishedYes

Fingerprint

Creatine
Adenosine Triphosphate
Mitochondria
Oxidative stress
Phosphocreatine
Cell membranes
Dietary Supplements
creatine transporter
Athletes
Muscle Cells
Neurons
Oxidative Stress
Heart Failure
Cell Membrane
Health
Tissue
Research

Keywords

  • Creatine
  • Creatine transport
  • Energy metabolism
  • Membrane transporter modulation

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Structural correlates of the creatine transporter function regulation : the undiscovered country. / Santacruz, Lucia; Jacobs, Danny.

In: Amino Acids, Vol. 48, No. 8, 01.08.2016, p. 2049-2055.

Research output: Contribution to journalReview article

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