Structural basis for the mechanics of the endothelial cell

Catherine Galbraith, Thomas Deerinck, Mark Ellisman, Richard Skalak, Shu Chien

Research output: Chapter in Book/Report/Conference proceedingConference contribution


In order to determine how the application of shear stress to cultured endothelial cell monolayers leads to cytoskeletal reorganization, it is necessary to have an accurate knowledge of the organization of the cytoskeletal proteins. We have performed triple labeling for actin, tubulin, and vimentin within cultured bovine aortic endothelial cells to determine the relative positions of these cytoskeletal components. This information, coupled with an analysis of the material properties of the microfilaments, microtubules, and intermediate filaments, suggests the hypothesis that the microtubules form the primary structure within the endothelial cell that resists the application of shear stress.

Original languageEnglish (US)
Title of host publicationAdvances in Bioengineering
EditorsJohn M. Tarbell
PublisherPubl by ASME
Number of pages3
ISBN (Print)0791810313
StatePublished - Dec 1 1993
Externally publishedYes
EventProceedings of the 1993 ASME Winter Annual Meeting - New Orleans, LA, USA
Duration: Nov 28 1993Dec 3 1993

Publication series

NameAmerican Society of Mechanical Engineers, Bioengineering Division (Publication) BED


OtherProceedings of the 1993 ASME Winter Annual Meeting
CityNew Orleans, LA, USA

ASJC Scopus subject areas

  • Engineering(all)


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