Structural aspects of the MHC expression control system

Grady Nash, Bhaskar Paidimuddala, Liman Zhang

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

The major histocompatibility complex (MHC) spans innate and adaptive immunity by presenting antigenic peptides to CD4+ and CD8+ T cells. Multiple transcription factors form an enhanceosome complex on the MHC promoter and recruit transcriptional machinery to activate gene transcription. Immune signals such as interferon-γ (IFN-γ) control MHC level by up-regulating components of the enhanceosome complex. As MHC plays crucial roles in immune regulation, alterations in the MHC enhanceosome structure will alter the pace of rapid immune responses at the transcription level and lead to various diseases related to the immune system. In this review, we discuss the current understanding of the MHC enhanceosome, with a focus on the structures of MHC enhanceosome components and the molecular basis of MHC enhanceosome assembly.

Original languageEnglish (US)
Article number106781
JournalBiophysical Chemistry
Volume284
DOIs
StatePublished - May 2022
Externally publishedYes

Keywords

  • CIITA
  • MHC enhanceosome
  • NLR
  • NLRC5
  • Proteins
  • Structural biology
  • Transcription factors

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Organic Chemistry

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