Structural alteration of viral homologue of receptor proto-oncogene fms at carboxyl terminus

Lisa Coussens, Charles Van Beveren, Douglas Smith, Ellson Chen, Richard L. Mitchell, Clare M. Isacke, Inder M. Verma, Axel Ullrich

Research output: Contribution to journalArticle

276 Citations (Scopus)

Abstract

A role for proto-oncogenes in the regulation and modulation of cell proliferation1,2 has been suggested by the findings that the B-chain of platelet-derived growth factor (PDGF) is encoded by the proto-oncogene sis3-7 and that the erb-B oncogene product is a truncated form of the epidermal growth factor (EGF) receptor8-10. Furthermore, the product of the proto-oncogene fms (c-fms) may be related or identical to the receptor for macrophage colony-stimulating factor (CSF-1)11. v-fms is the transforming gene of the McDonough strain of feline sarcoma virus (SM-FeSV) 12,13 and belongs to the family of src-related oncogenes which have tyrosine-specific kinase activity. Furthermore, nucleo-tide sequence analysis of the v-fms gene product revealed topologi-cal properties of a cell-surface receptor protein14. To elucidate the features involved in the conversion of a normal cell-surface receptor gene into an oncogenic one, we have now determined the complete nucleotide sequence of a human c-fms complementary DNA. The 972-amino-acid c-fms protein has an extracellular domain, a membrane-spanning region, and a cytoplasmic tyrosine protein kinase domain. Comparison of the feline v-fms and human c-fms sequences reveals that the proteins share extensive homology but have different carboxyl termini.

Original languageEnglish (US)
Pages (from-to)277-280
Number of pages4
JournalNature
Volume320
Issue number6059
DOIs
StatePublished - 1986
Externally publishedYes

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fms Genes
Macrophage Colony-Stimulating Factor
Proto-Oncogenes
Cell Surface Receptors
Protein-Tyrosine Kinases
Feline Sarcoma Viruses
Macrophage Colony-Stimulating Factor Receptors
src Genes
Proto-Oncogene Proteins c-sis
Oncogene Proteins
Felidae
Oncogenes
Epidermal Growth Factor
Sequence Analysis
Complementary DNA
Macrophages
Amino Acids
Membranes
Genes
Proteins

ASJC Scopus subject areas

  • General

Cite this

Coussens, L., Van Beveren, C., Smith, D., Chen, E., Mitchell, R. L., Isacke, C. M., ... Ullrich, A. (1986). Structural alteration of viral homologue of receptor proto-oncogene fms at carboxyl terminus. Nature, 320(6059), 277-280. https://doi.org/10.1038/320277a0

Structural alteration of viral homologue of receptor proto-oncogene fms at carboxyl terminus. / Coussens, Lisa; Van Beveren, Charles; Smith, Douglas; Chen, Ellson; Mitchell, Richard L.; Isacke, Clare M.; Verma, Inder M.; Ullrich, Axel.

In: Nature, Vol. 320, No. 6059, 1986, p. 277-280.

Research output: Contribution to journalArticle

Coussens, L, Van Beveren, C, Smith, D, Chen, E, Mitchell, RL, Isacke, CM, Verma, IM & Ullrich, A 1986, 'Structural alteration of viral homologue of receptor proto-oncogene fms at carboxyl terminus', Nature, vol. 320, no. 6059, pp. 277-280. https://doi.org/10.1038/320277a0
Coussens, Lisa ; Van Beveren, Charles ; Smith, Douglas ; Chen, Ellson ; Mitchell, Richard L. ; Isacke, Clare M. ; Verma, Inder M. ; Ullrich, Axel. / Structural alteration of viral homologue of receptor proto-oncogene fms at carboxyl terminus. In: Nature. 1986 ; Vol. 320, No. 6059. pp. 277-280.
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