Strong relation between muscle mass determined by d3-creatine dilution, physical performance, and incidence of falls and mobility limitations in a prospective cohort of older men

Peggy M. Cawthon, Eric S. Orwoll, Katherine E. Peters, Kristine E. Ensrud, Jane A. Cauley, Deborah M. Kado, Marcia L. Stefanick, James M. Shikany, Elsa S. Strotmeyer, Nancy W. Glynn, Paolo Caserotti, Mahalakshmi Shankaran, Marc Hellerstein, Steven R. Cummings, William J. Evans

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Background: Direct assessment of skeletal muscle mass in older adults is clinically challenging. Relationships between lean mass and late-life outcomes have been inconsistent. The D3-creatine dilution method provides a direct assessment of muscle mass. Methods: Muscle mass was assessed by D3-creatine (D3Cr) dilution in 1,382 men (mean age, 84.2 years). Participants completed the Short Physical Performance Battery (SPPB); usual walking speed (6 m); and dual x-ray absorptiometry (DXA) lean mass. Men self-reported mobility limitations (difficulty walking 2-3 blocks or climbing 10 steps); recurrent falls (2+); and serious injurious falls in the subsequent year. Acrossquartiles of D3Cr muscle mass/body mass, multivariate linear models calculated means for SPPB and gait speed; multivariate logistic models calculated odds ratios for incident mobility limitations or falls. Results: Compared to men in the highest quartile, those in the lowest quartile of D3Cr muscle mass/body mass had slower gait speed (Q1: 1.04 vs Q4: 1.17 m/s); lower SPPB (Q1: 8.4 vs Q4: 10.4 points); greater likelihood of incident serious injurious falls (odds ratio [OR] Q1 vs Q4: 2.49, 95% confidence interval [CI]: 1.37, 4.54); prevalent mobility limitation (OR Q1 vs Q4,: 6.1, 95% CI: 3.7, 10.3) and incident mobility limitation (OR Q1 vs Q4: 2.15 95% CI: 1.42, 3.26); p for trend < .001 for all. Results for incident recurrent falls were in the similar direction (p = .156). DXA lean mass had weaker associations with the outcomes. Conclusions: Unlike DXA lean mass, low D3Cr muscle mass/body mass is strongly related to physical performance, mobility, and incident injurious falls in older men.

Original languageEnglish (US)
Pages (from-to)844-852
Number of pages9
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume74
Issue number6
DOIs
StatePublished - 2019

Keywords

  • Falls
  • Functional performance
  • Muscle
  • Sarcopenia

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

Fingerprint Dive into the research topics of 'Strong relation between muscle mass determined by d3-creatine dilution, physical performance, and incidence of falls and mobility limitations in a prospective cohort of older men'. Together they form a unique fingerprint.

  • Cite this

    Cawthon, P. M., Orwoll, E. S., Peters, K. E., Ensrud, K. E., Cauley, J. A., Kado, D. M., Stefanick, M. L., Shikany, J. M., Strotmeyer, E. S., Glynn, N. W., Caserotti, P., Shankaran, M., Hellerstein, M., Cummings, S. R., & Evans, W. J. (2019). Strong relation between muscle mass determined by d3-creatine dilution, physical performance, and incidence of falls and mobility limitations in a prospective cohort of older men. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 74(6), 844-852. https://doi.org/10.1093/gerona/gly129