A BUSCA DE EQUILIBRIO ENTRE SEGURANCA E EFICACIA

EXPERIENCIA COM O ISRS SERTRALINA

Translated title of the contribution: Striking a balance between safety and efficacy: Experience with the SSRI sertraline

Daniel Casey

Research output: Contribution to journalArticle

Abstract

Depression is a widespread and serious disorder inflicting an immeasurable toll on the lives of millions of people and affecting their families and colleagues. It is the cause of countless suicides especially in those whose illness has not been detected or given appropriate care. Until recently, effective pharmacotherapeutic management of depression was hampered by the troublesome side effects associated with traditional methods of treatment. In an attempt to circumvent these adverse effects, many antidepressants were prescribed at less then therapeutic doses, resulting in a high probability of inadequate treatment, relapse, or recurrence. The development of the selective serotonin reuptake inhibitors (SSRIs) was guided by the need for an antidepressant that provided both safe and effective therapeutic benefit. Sertraline's potent and highly selective inhibition of serotonin accounts both for its efficacy in a broad spectrum of depression and for its high tolerability and ease of use. Its safety and tolerability have been demonstrated in acute and maintenance phases of treatment and establishes that sertraline provides a viable clinical alternative for acute and long-term care of depressed patients.

Original languageUndefined
JournalJornal Brasileiro de Psiquiatria
Volume43
Issue numberSUPPL. 2
StatePublished - 1994
Externally publishedYes

Fingerprint

Sertraline
Serotonin Uptake Inhibitors
Safety
Depression
Antidepressive Agents
Therapeutics
Recurrence
Long-Term Care
Suicide
Serotonin
Maintenance

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

A BUSCA DE EQUILIBRIO ENTRE SEGURANCA E EFICACIA : EXPERIENCIA COM O ISRS SERTRALINA. / Casey, Daniel.

In: Jornal Brasileiro de Psiquiatria, Vol. 43, No. SUPPL. 2, 1994.

Research output: Contribution to journalArticle

@article{1d358f4e6ce34295b6c040adb93a0ee7,
title = "A BUSCA DE EQUILIBRIO ENTRE SEGURANCA E EFICACIA: EXPERIENCIA COM O ISRS SERTRALINA",
abstract = "Depression is a widespread and serious disorder inflicting an immeasurable toll on the lives of millions of people and affecting their families and colleagues. It is the cause of countless suicides especially in those whose illness has not been detected or given appropriate care. Until recently, effective pharmacotherapeutic management of depression was hampered by the troublesome side effects associated with traditional methods of treatment. In an attempt to circumvent these adverse effects, many antidepressants were prescribed at less then therapeutic doses, resulting in a high probability of inadequate treatment, relapse, or recurrence. The development of the selective serotonin reuptake inhibitors (SSRIs) was guided by the need for an antidepressant that provided both safe and effective therapeutic benefit. Sertraline's potent and highly selective inhibition of serotonin accounts both for its efficacy in a broad spectrum of depression and for its high tolerability and ease of use. Its safety and tolerability have been demonstrated in acute and maintenance phases of treatment and establishes that sertraline provides a viable clinical alternative for acute and long-term care of depressed patients.",
author = "Daniel Casey",
year = "1994",
language = "Undefined",
volume = "43",
journal = "Jornal Brasileiro de Psiquiatria",
issn = "0047-2085",
publisher = "Editora Cientifica Nacional Ltda",
number = "SUPPL. 2",

}

TY - JOUR

T1 - A BUSCA DE EQUILIBRIO ENTRE SEGURANCA E EFICACIA

T2 - EXPERIENCIA COM O ISRS SERTRALINA

AU - Casey, Daniel

PY - 1994

Y1 - 1994

N2 - Depression is a widespread and serious disorder inflicting an immeasurable toll on the lives of millions of people and affecting their families and colleagues. It is the cause of countless suicides especially in those whose illness has not been detected or given appropriate care. Until recently, effective pharmacotherapeutic management of depression was hampered by the troublesome side effects associated with traditional methods of treatment. In an attempt to circumvent these adverse effects, many antidepressants were prescribed at less then therapeutic doses, resulting in a high probability of inadequate treatment, relapse, or recurrence. The development of the selective serotonin reuptake inhibitors (SSRIs) was guided by the need for an antidepressant that provided both safe and effective therapeutic benefit. Sertraline's potent and highly selective inhibition of serotonin accounts both for its efficacy in a broad spectrum of depression and for its high tolerability and ease of use. Its safety and tolerability have been demonstrated in acute and maintenance phases of treatment and establishes that sertraline provides a viable clinical alternative for acute and long-term care of depressed patients.

AB - Depression is a widespread and serious disorder inflicting an immeasurable toll on the lives of millions of people and affecting their families and colleagues. It is the cause of countless suicides especially in those whose illness has not been detected or given appropriate care. Until recently, effective pharmacotherapeutic management of depression was hampered by the troublesome side effects associated with traditional methods of treatment. In an attempt to circumvent these adverse effects, many antidepressants were prescribed at less then therapeutic doses, resulting in a high probability of inadequate treatment, relapse, or recurrence. The development of the selective serotonin reuptake inhibitors (SSRIs) was guided by the need for an antidepressant that provided both safe and effective therapeutic benefit. Sertraline's potent and highly selective inhibition of serotonin accounts both for its efficacy in a broad spectrum of depression and for its high tolerability and ease of use. Its safety and tolerability have been demonstrated in acute and maintenance phases of treatment and establishes that sertraline provides a viable clinical alternative for acute and long-term care of depressed patients.

UR - http://www.scopus.com/inward/record.url?scp=0028578119&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028578119&partnerID=8YFLogxK

M3 - Article

VL - 43

JO - Jornal Brasileiro de Psiquiatria

JF - Jornal Brasileiro de Psiquiatria

SN - 0047-2085

IS - SUPPL. 2

ER -