Striatal responses to decortication. I. Dopaminergic and astrocytic activities

G. M. Pasinetti, Steven Kohama, J. F. Reinhard, H. W. Cheng, T. H. McNeill, C. E. Finch

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Unilateral ablation of the frontal cortex induced 30%-50% decrease of dopamine (DA) concentration in the ipsilateral striatum at 10 and 27 days after lesioning. There were increased ratios of dihydroxyphenylacetic acid (DOPAC): DA and homovanillic acid (HVA): DA by 20%-60% at 10 days post-lesioning, which suggest compensatory increases of DA metabolism. While no change in total striatal tyrosine hydroxylase (TH) polypeptide concentration was found at any post-lesion time, TH catalytic activity was decreased slightly (-25%) at 10 days. Among individual rats, at 3, 10 and 27 days post-lesioning, striatal DA concentration was inversely related to striatal glial fibrillary acidic protein (GFAP) concentration, a marker of astrocytic activity. The loss of DA was observed whether or not DA was normalized to striatal protein, which suggests that DA loss cannot be simply attributed to increased astrocytic proteins. These data suggest reciprocal relationships between the extent of astrocytic reactions after cortical deafferentation and striatal DA loss, which could involve local remodelling without primary damage to the nigro-striatal terminals.

Original languageEnglish (US)
Pages (from-to)253-259
Number of pages7
JournalBrain Research
Volume567
Issue number2
DOIs
StatePublished - Dec 20 1991
Externally publishedYes

Fingerprint

Corpus Striatum
Dopamine
Tyrosine 3-Monooxygenase
Homovanillic Acid
Glial Fibrillary Acidic Protein
Frontal Lobe
Proteins
Peptides
Acids

Keywords

  • Deafferentation
  • Dopamine
  • Glial fibrillary acidic protein
  • Immunocytochemistry
  • Striatum
  • Tyrosine hydroxylase

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Pasinetti, G. M., Kohama, S., Reinhard, J. F., Cheng, H. W., McNeill, T. H., & Finch, C. E. (1991). Striatal responses to decortication. I. Dopaminergic and astrocytic activities. Brain Research, 567(2), 253-259. https://doi.org/10.1016/0006-8993(91)90803-4

Striatal responses to decortication. I. Dopaminergic and astrocytic activities. / Pasinetti, G. M.; Kohama, Steven; Reinhard, J. F.; Cheng, H. W.; McNeill, T. H.; Finch, C. E.

In: Brain Research, Vol. 567, No. 2, 20.12.1991, p. 253-259.

Research output: Contribution to journalArticle

Pasinetti, GM, Kohama, S, Reinhard, JF, Cheng, HW, McNeill, TH & Finch, CE 1991, 'Striatal responses to decortication. I. Dopaminergic and astrocytic activities', Brain Research, vol. 567, no. 2, pp. 253-259. https://doi.org/10.1016/0006-8993(91)90803-4
Pasinetti GM, Kohama S, Reinhard JF, Cheng HW, McNeill TH, Finch CE. Striatal responses to decortication. I. Dopaminergic and astrocytic activities. Brain Research. 1991 Dec 20;567(2):253-259. https://doi.org/10.1016/0006-8993(91)90803-4
Pasinetti, G. M. ; Kohama, Steven ; Reinhard, J. F. ; Cheng, H. W. ; McNeill, T. H. ; Finch, C. E. / Striatal responses to decortication. I. Dopaminergic and astrocytic activities. In: Brain Research. 1991 ; Vol. 567, No. 2. pp. 253-259.
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