Striatal involvement in human alcoholism and alcohol consumption, and withdrawal in animal models

Gang Chen, Verginia Cuzon Carlson, Jun Wang, Anne Beck, Andreas Heinz, Dorit Ron, David M. Lovinger, Kari Buck

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Background: Different regions of the striatum may have distinct roles in acute intoxication, alcohol seeking, dependence, and withdrawal. Methods: The recent advances are reviewed and discussed in our understanding of the role of the dorsolateral striatum (DLS), dorsomedial striatum (DMS), and ventral striatum in behavioral responses to alcohol, including alcohol craving in abstinent alcoholics, and alcohol consumption and withdrawal in rat, mouse, and nonhuman primate models. Results: Reduced neuronal activity as well as dysfunctional connectivity between the ventral striatum and the dorsolateral prefrontal cortex is associated with alcohol craving and impairment of new learning processes in abstinent alcoholics. Within the DLS of mice and nonhuman primates withdrawn from alcohol after chronic exposure, glutamatergic transmission in striatal projection neurons is increased, while GABAergic transmission is decreased. Glutamatergic transmission in DMS projection neurons is also increased in ethanol withdrawn rats. Ex vivo or in vivo ethanol exposure and withdrawal causes a long-lasting increase in NR2B subunit-containing NMDA receptor activity in the DMS, contributing to ethanol drinking. Analyses of neuronal activation associated with alcohol withdrawal and site-directed lesions in mice implicate the rostroventral caudate putamen, a ventrolateral segment of the DMS, in genetically determined differences in risk for alcohol withdrawal involved in physical association of the multi-PDZ domain protein, MPDZ, with 5-HT 2C receptors and/or NR2B. Conclusions: Alterations of dopaminergic, glutamatergic, and GABAergic signaling within different regions of the striatum by alcohol is critical for alcohol craving, consumption, dependence, and withdrawal in humans and animal models.

Original languageEnglish (US)
Pages (from-to)1739-1748
Number of pages10
JournalAlcoholism: Clinical and Experimental Research
Volume35
Issue number10
DOIs
StatePublished - Oct 2011

Fingerprint

Corpus Striatum
Alcohol Drinking
Alcoholism
Animals
Animal Models
Alcohols
Ethanol
Alcoholics
Primates
Receptor, Serotonin, 5-HT2C
PDZ Domains
Activation Analysis
Neurons
Rats
Putamen
Prefrontal Cortex
N-Methyl-D-Aspartate Receptors
Drinking
Learning
Chemical activation

Keywords

  • C-Fos
  • Electrophysiology
  • FMRI
  • Fyn kinase
  • PET
  • Self-Administration

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Psychiatry and Mental health
  • Toxicology

Cite this

Striatal involvement in human alcoholism and alcohol consumption, and withdrawal in animal models. / Chen, Gang; Cuzon Carlson, Verginia; Wang, Jun; Beck, Anne; Heinz, Andreas; Ron, Dorit; Lovinger, David M.; Buck, Kari.

In: Alcoholism: Clinical and Experimental Research, Vol. 35, No. 10, 10.2011, p. 1739-1748.

Research output: Contribution to journalArticle

Chen, Gang ; Cuzon Carlson, Verginia ; Wang, Jun ; Beck, Anne ; Heinz, Andreas ; Ron, Dorit ; Lovinger, David M. ; Buck, Kari. / Striatal involvement in human alcoholism and alcohol consumption, and withdrawal in animal models. In: Alcoholism: Clinical and Experimental Research. 2011 ; Vol. 35, No. 10. pp. 1739-1748.
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