Stria vascularis ultrastructural pathology in the C3H/lpr autoimmune strain mouse

A potential mechanism for immune-related hearing loss

S. O. McMenomey, N. J. Russell, J. I. Morton, Dennis Trune

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The stria vascularis in the C3H/lpr autoimmune strain mouse was ultrastructurally examined in order to better understand the potential mechanisms by which systemic autoimmune disease affects the ear. The inner ears from C3H/lpr mice before disease onset and C3H/HeJ controls showed no apparent pathology. However, the stria vascularis from older C3H/lpr mice after systemic autoimmune disease onset showed considerable intercellular edema around the stria capillaries and thickening of the capillary basement membrane, compared to controls. These observations suggest that perivascular abnormalities, which are the hallmark of systemic autoimmune diseases, may underlie the stria dysfunction and hearing loss seen in autoimmune diseases in humans.

Original languageEnglish (US)
Pages (from-to)288-295
Number of pages8
JournalOtolaryngology - Head and Neck Surgery
Volume106
Issue number3
StatePublished - 1992

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Stria Vascularis
Hearing Loss
Autoimmune Diseases
Pathology
Inbred C3H Mouse
Inner Ear
Basement Membrane
Ear
Edema

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Stria vascularis ultrastructural pathology in the C3H/lpr autoimmune strain mouse : A potential mechanism for immune-related hearing loss. / McMenomey, S. O.; Russell, N. J.; Morton, J. I.; Trune, Dennis.

In: Otolaryngology - Head and Neck Surgery, Vol. 106, No. 3, 1992, p. 288-295.

Research output: Contribution to journalArticle

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