Stria vascularis ultrastructural pathology in the C3H/lpr autoimmune strain mouse: A potential mechanism for immune-related hearing loss

S. O. McMenomey; N. J. Russell; J. I. Morton; D. R. Trune

doi:10.1177/019459989210600317

Stria vascularis ultrastructural pathology in the C3H/lpr autoimmune strain mouse: A potential mechanism for immune-related hearing loss

S. O. McMenomey, N. J. Russell, J. I. Morton, D. R. Trune

Otolaryngology

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

The stria vascularis in the C3H/lpr autoimmune strain mouse was ultrastructurally examined in order to better understand the potential mechanisms by which systemic autoimmune disease affects the ear. The inner ears from C3H/lpr mice before disease onset and C3H/HeJ controls showed no apparent pathology. However, the stria vascularis from older C3H/lpr mice after systemic autoimmune disease onset showed considerable intercellular edema around the stria capillaries and thickening of the capillary basement membrane, compared to controls. These observations suggest that perivascular abnormalities, which are the hallmark of systemic autoimmune diseases, may underlie the stria dysfunction and hearing loss seen in autoimmune diseases in humans.

Original language	English (US)
Pages (from-to)	288-295
Number of pages	8
Journal	Otolaryngology - Head and Neck Surgery
Volume	106
Issue number	3
DOIs	https://doi.org/10.1177/019459989210600317
State	Published - 1992

ASJC Scopus subject areas

Surgery
Otorhinolaryngology

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title = "Stria vascularis ultrastructural pathology in the C3H/lpr autoimmune strain mouse: A potential mechanism for immune-related hearing loss",

abstract = "The stria vascularis in the C3H/lpr autoimmune strain mouse was ultrastructurally examined in order to better understand the potential mechanisms by which systemic autoimmune disease affects the ear. The inner ears from C3H/lpr mice before disease onset and C3H/HeJ controls showed no apparent pathology. However, the stria vascularis from older C3H/lpr mice after systemic autoimmune disease onset showed considerable intercellular edema around the stria capillaries and thickening of the capillary basement membrane, compared to controls. These observations suggest that perivascular abnormalities, which are the hallmark of systemic autoimmune diseases, may underlie the stria dysfunction and hearing loss seen in autoimmune diseases in humans.",

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AU - Morton, J. I.

AU - Trune, D. R.

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AB - The stria vascularis in the C3H/lpr autoimmune strain mouse was ultrastructurally examined in order to better understand the potential mechanisms by which systemic autoimmune disease affects the ear. The inner ears from C3H/lpr mice before disease onset and C3H/HeJ controls showed no apparent pathology. However, the stria vascularis from older C3H/lpr mice after systemic autoimmune disease onset showed considerable intercellular edema around the stria capillaries and thickening of the capillary basement membrane, compared to controls. These observations suggest that perivascular abnormalities, which are the hallmark of systemic autoimmune diseases, may underlie the stria dysfunction and hearing loss seen in autoimmune diseases in humans.

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Stria vascularis ultrastructural pathology in the C3H/lpr autoimmune strain mouse: A potential mechanism for immune-related hearing loss

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