Stress-specific modulation of ACTH secretion by oxytocin

Daniel M. Gibbs

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

The role of oxytocin (OT) in regulating stress-induced ACTH secretion was investigated by immunoneutnilization of endogenous OT with an antiserum raised against synthetic OT. Rats were subjected to one of three stresses: Novel environment, tail-hang, or ether. In otherwise untreated rats, ACTH levels rose at least 3-fold in response to all three stresses whereas OT levels increased only in response; to tail-bang and ether. Injection of a highly specific antiserum to OT 60 min before the experiment inhibited the ACTH response to tail-hang and ether by 64 and 56%, respectively, but had no effect on the ACTH response to novel environment stress. The data support a physiologic role for OT in the control of ACTH secretion but suggest that it is not until OT levels rise in response to stress that the effects of OT are expressed.

Original languageEnglish (US)
Pages (from-to)456-458
Number of pages3
JournalNeuroendocrinology
Volume42
Issue number6
DOIs
StatePublished - Jan 1 1986

Keywords

  • ACTH
  • Oxytocin
  • Stress
  • Vasopressin

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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