Stress-related neuropeptides and alcoholism: CRH, NPY, and beyond

Roberto Ciccocioppo; Donald R. Gehlert; Andrey Ryabinin; Simranjit Kaur; Andrea Cippitelli; Annika Thorsell; Anh D. Lê; Philip A. Hipskind; Chafiq Hamdouchi; Jianliang Lu; Erik J. Hembre; Jeffrey Cramer; Min Song; David McKinzie; Michelle Morin; Daina Economidou; Serena Stopponi; Nazzareno Cannella; Simone Braconi; Marsida Kallupi; Giordano de Guglielmo; Maurizio Massi; David T. George; Jody Gilman; Jacqueline Hersh; Johannes T. Tauscher; Stephen P. Hunt; Daniel Hommer; Markus Heilig

doi:10.1016/j.alcohol.2009.08.003

Stress-related neuropeptides and alcoholism: CRH, NPY, and beyond

Roberto Ciccocioppo, Donald R. Gehlert, Andrey Ryabinin, Simranjit Kaur, Andrea Cippitelli, Annika Thorsell, Anh D. Lê, Philip A. Hipskind, Chafiq Hamdouchi, Jianliang Lu, Erik J. Hembre, Jeffrey Cramer, Min Song, David McKinzie, Michelle Morin, Daina Economidou, Serena Stopponi, Nazzareno Cannella, Simone Braconi, Marsida KallupiGiordano de Guglielmo, Maurizio Massi, David T. George, Jody Gilman, Jacqueline Hersh, Johannes T. Tauscher, Stephen P. Hunt, Daniel Hommer, Markus Heilig

Behavioral Neuroscience

Research output: Contribution to journal › Review article › peer-review

55 Scopus citations

Abstract

This article summarizes the proceedings of a symposium held at the conference on "Alcoholism and Stress: A Framework for Future Treatment Strategies" in Volterra, Italy, May 6-9, 2008. Chaired by Markus Heilig and Roberto Ciccocioppo, this symposium offered a forum for the presentation of recent data linking neuropetidergic neurotransmission to the regulation of different alcohol-related behaviors in animals and in humans. Dr. Donald Gehlert described the development of a new corticotrophin-releasing factor receptor 1 antagonist and showed its efficacy in reducing alcohol consumption and stress-induced relapse in different animal models of alcohol abuse. Dr. Andrey Ryabinin reviewed recent findings in his laboratory, indicating a role of the urocortin 1 receptor system in the regulation of alcohol intake. Dr. Annika Thorsell showed data supporting the significance of the neuropeptide Y receptor system in the modulation of behaviors associated with a history of ethanol intoxication. Dr. Roberto Ciccocioppo focused his presentation on the nociceptin/orphanin FQ (N/OFQ) receptors as treatment targets for alcoholism. Finally, Dr. Markus Heilig showed recent preclinical and clinical evidence suggesting that neurokinin 1 antagonism may represent a promising new treatment for alcoholism. Collectively, these investigators highlighted the significance of neuropeptidergic neurotransmission in the regulation of neurobiological mechanisms of alcohol addiction. Data also revealed the importance of these systems as treatment targets for the development of new medication for alcoholism.

Original language	English (US)
Pages (from-to)	491-498
Number of pages	8
Journal	Alcohol
Volume	43
Issue number	7
DOIs	https://doi.org/10.1016/j.alcohol.2009.08.003
State	Published - Nov 2009

Keywords

CRH
Neurokinins
Neuropeptide Y
Nociceptin/orphanin FQ
Substance P
Urocortin

ASJC Scopus subject areas

Health(social science)
Biochemistry
Toxicology
Neurology
Behavioral Neuroscience

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10.1016/j.alcohol.2009.08.003

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Ciccocioppo, R., Gehlert, D. R., Ryabinin, A., Kaur, S., Cippitelli, A., Thorsell, A., Lê, A. D., Hipskind, P. A., Hamdouchi, C., Lu, J., Hembre, E. J., Cramer, J., Song, M., McKinzie, D., Morin, M., Economidou, D., Stopponi, S., Cannella, N., Braconi, S., ... Heilig, M. (2009). Stress-related neuropeptides and alcoholism: CRH, NPY, and beyond. Alcohol, 43(7), 491-498. https://doi.org/10.1016/j.alcohol.2009.08.003

Ciccocioppo, R, Gehlert, DR, Ryabinin, A, Kaur, S, Cippitelli, A, Thorsell, A, Lê, AD, Hipskind, PA, Hamdouchi, C, Lu, J, Hembre, EJ, Cramer, J, Song, M, McKinzie, D, Morin, M, Economidou, D, Stopponi, S, Cannella, N, Braconi, S, Kallupi, M, de Guglielmo, G, Massi, M, George, DT, Gilman, J, Hersh, J, Tauscher, JT, Hunt, SP, Hommer, D & Heilig, M 2009, 'Stress-related neuropeptides and alcoholism: CRH, NPY, and beyond', Alcohol, vol. 43, no. 7, pp. 491-498. https://doi.org/10.1016/j.alcohol.2009.08.003

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title = "Stress-related neuropeptides and alcoholism: CRH, NPY, and beyond",

abstract = "This article summarizes the proceedings of a symposium held at the conference on {"}Alcoholism and Stress: A Framework for Future Treatment Strategies{"} in Volterra, Italy, May 6-9, 2008. Chaired by Markus Heilig and Roberto Ciccocioppo, this symposium offered a forum for the presentation of recent data linking neuropetidergic neurotransmission to the regulation of different alcohol-related behaviors in animals and in humans. Dr. Donald Gehlert described the development of a new corticotrophin-releasing factor receptor 1 antagonist and showed its efficacy in reducing alcohol consumption and stress-induced relapse in different animal models of alcohol abuse. Dr. Andrey Ryabinin reviewed recent findings in his laboratory, indicating a role of the urocortin 1 receptor system in the regulation of alcohol intake. Dr. Annika Thorsell showed data supporting the significance of the neuropeptide Y receptor system in the modulation of behaviors associated with a history of ethanol intoxication. Dr. Roberto Ciccocioppo focused his presentation on the nociceptin/orphanin FQ (N/OFQ) receptors as treatment targets for alcoholism. Finally, Dr. Markus Heilig showed recent preclinical and clinical evidence suggesting that neurokinin 1 antagonism may represent a promising new treatment for alcoholism. Collectively, these investigators highlighted the significance of neuropeptidergic neurotransmission in the regulation of neurobiological mechanisms of alcohol addiction. Data also revealed the importance of these systems as treatment targets for the development of new medication for alcoholism.",

keywords = "CRH, Neurokinins, Neuropeptide Y, Nociceptin/orphanin FQ, Substance P, Urocortin",

author = "Roberto Ciccocioppo and Gehlert, {Donald R.} and Andrey Ryabinin and Simranjit Kaur and Andrea Cippitelli and Annika Thorsell and L{\^e}, {Anh D.} and Hipskind, {Philip A.} and Chafiq Hamdouchi and Jianliang Lu and Hembre, {Erik J.} and Jeffrey Cramer and Min Song and David McKinzie and Michelle Morin and Daina Economidou and Serena Stopponi and Nazzareno Cannella and Simone Braconi and Marsida Kallupi and {de Guglielmo}, Giordano and Maurizio Massi and George, {David T.} and Jody Gilman and Jacqueline Hersh and Tauscher, {Johannes T.} and Hunt, {Stephen P.} and Daniel Hommer and Markus Heilig",

note = "Funding Information: This work was supported by NIH grants: AA01435 (to FW subcontract to R.C.), AA013738 (to A.R.), and AA016647 (to A.R.).",

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doi = "10.1016/j.alcohol.2009.08.003",

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AU - Kaur, Simranjit

AU - Cippitelli, Andrea

AU - Thorsell, Annika

AU - Lê, Anh D.

AU - Hipskind, Philip A.

AU - Hamdouchi, Chafiq

AU - Lu, Jianliang

AU - Hembre, Erik J.

AU - Cramer, Jeffrey

AU - Song, Min

AU - McKinzie, David

AU - Morin, Michelle

AU - Economidou, Daina

AU - Stopponi, Serena

AU - Cannella, Nazzareno

AU - Braconi, Simone

AU - Kallupi, Marsida

AU - de Guglielmo, Giordano

AU - Massi, Maurizio

AU - George, David T.

AU - Gilman, Jody

AU - Hersh, Jacqueline

AU - Tauscher, Johannes T.

AU - Hunt, Stephen P.

AU - Hommer, Daniel

AU - Heilig, Markus

N1 - Funding Information: This work was supported by NIH grants: AA01435 (to FW subcontract to R.C.), AA013738 (to A.R.), and AA016647 (to A.R.).

PY - 2009/11

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N2 - This article summarizes the proceedings of a symposium held at the conference on "Alcoholism and Stress: A Framework for Future Treatment Strategies" in Volterra, Italy, May 6-9, 2008. Chaired by Markus Heilig and Roberto Ciccocioppo, this symposium offered a forum for the presentation of recent data linking neuropetidergic neurotransmission to the regulation of different alcohol-related behaviors in animals and in humans. Dr. Donald Gehlert described the development of a new corticotrophin-releasing factor receptor 1 antagonist and showed its efficacy in reducing alcohol consumption and stress-induced relapse in different animal models of alcohol abuse. Dr. Andrey Ryabinin reviewed recent findings in his laboratory, indicating a role of the urocortin 1 receptor system in the regulation of alcohol intake. Dr. Annika Thorsell showed data supporting the significance of the neuropeptide Y receptor system in the modulation of behaviors associated with a history of ethanol intoxication. Dr. Roberto Ciccocioppo focused his presentation on the nociceptin/orphanin FQ (N/OFQ) receptors as treatment targets for alcoholism. Finally, Dr. Markus Heilig showed recent preclinical and clinical evidence suggesting that neurokinin 1 antagonism may represent a promising new treatment for alcoholism. Collectively, these investigators highlighted the significance of neuropeptidergic neurotransmission in the regulation of neurobiological mechanisms of alcohol addiction. Data also revealed the importance of these systems as treatment targets for the development of new medication for alcoholism.

AB - This article summarizes the proceedings of a symposium held at the conference on "Alcoholism and Stress: A Framework for Future Treatment Strategies" in Volterra, Italy, May 6-9, 2008. Chaired by Markus Heilig and Roberto Ciccocioppo, this symposium offered a forum for the presentation of recent data linking neuropetidergic neurotransmission to the regulation of different alcohol-related behaviors in animals and in humans. Dr. Donald Gehlert described the development of a new corticotrophin-releasing factor receptor 1 antagonist and showed its efficacy in reducing alcohol consumption and stress-induced relapse in different animal models of alcohol abuse. Dr. Andrey Ryabinin reviewed recent findings in his laboratory, indicating a role of the urocortin 1 receptor system in the regulation of alcohol intake. Dr. Annika Thorsell showed data supporting the significance of the neuropeptide Y receptor system in the modulation of behaviors associated with a history of ethanol intoxication. Dr. Roberto Ciccocioppo focused his presentation on the nociceptin/orphanin FQ (N/OFQ) receptors as treatment targets for alcoholism. Finally, Dr. Markus Heilig showed recent preclinical and clinical evidence suggesting that neurokinin 1 antagonism may represent a promising new treatment for alcoholism. Collectively, these investigators highlighted the significance of neuropeptidergic neurotransmission in the regulation of neurobiological mechanisms of alcohol addiction. Data also revealed the importance of these systems as treatment targets for the development of new medication for alcoholism.

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KW - Nociceptin/orphanin FQ

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KW - Urocortin

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Stress-related neuropeptides and alcoholism: CRH, NPY, and beyond

Abstract

Keywords

ASJC Scopus subject areas

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