Stress-related changes in proinflammatory cytokine production in wounds

Ronald Glaser, Janice K. Kiecolt-Glaser, Phillip Marucha, Robert C. MacCallum, Bryon F. Laskowski, William B. Malarkey

Research output: Contribution to journalArticle

230 Citations (Scopus)

Abstract

Background: Several recent studies have shown that stress markedly delays wound healing. This study assessed the relationship between psychological stress and the secretion of proinflammatory cytokines at an actual wound site, providing in vivo data on the development of local immune responses that are central in the early stages of wound repair. Methods: To study the dynamics of inflammation, skin blisters were induced on the forearm of 36 women (mean age, 57 years) by suction. After the blister roofs were removed, a plastic template was taped to the arm, and wells were filled with 70% autologous serum in buffer. Specimens were aspirated from blister chamber wells 5 and 24 hours after wounding. Results: Women with higher perceived stress scores demonstrated significantly lower levels of 2 key cytokines - interleukin 1α and interleukin 8 - at wound sites. In addition, subjects who had low levels of both cytokines after 24 hours reported more stress and negative affect, and they had higher levels of salivary cortisol than those who had high cytokine levels. Conclusion: Consistent with the evidence that stress delays wound healing, these data suggest a possible mechanism: psychological stress has measurable effects on proinflammatory cytokine production in the local wound environment.

Original languageEnglish (US)
Pages (from-to)450-456
Number of pages7
JournalArchives of General Psychiatry
Volume56
Issue number5
DOIs
StatePublished - May 1999
Externally publishedYes

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Cytokines
Blister
Wounds and Injuries
Psychological Stress
Wound Healing
Suction
Interleukin-8
Interleukin-1
Forearm
Plastics
Hydrocortisone
Buffers
Arm
Inflammation
Skin
Serum

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Glaser, R., Kiecolt-Glaser, J. K., Marucha, P., MacCallum, R. C., Laskowski, B. F., & Malarkey, W. B. (1999). Stress-related changes in proinflammatory cytokine production in wounds. Archives of General Psychiatry, 56(5), 450-456. https://doi.org/10.1001/archpsyc.56.5.450

Stress-related changes in proinflammatory cytokine production in wounds. / Glaser, Ronald; Kiecolt-Glaser, Janice K.; Marucha, Phillip; MacCallum, Robert C.; Laskowski, Bryon F.; Malarkey, William B.

In: Archives of General Psychiatry, Vol. 56, No. 5, 05.1999, p. 450-456.

Research output: Contribution to journalArticle

Glaser, R, Kiecolt-Glaser, JK, Marucha, P, MacCallum, RC, Laskowski, BF & Malarkey, WB 1999, 'Stress-related changes in proinflammatory cytokine production in wounds', Archives of General Psychiatry, vol. 56, no. 5, pp. 450-456. https://doi.org/10.1001/archpsyc.56.5.450
Glaser, Ronald ; Kiecolt-Glaser, Janice K. ; Marucha, Phillip ; MacCallum, Robert C. ; Laskowski, Bryon F. ; Malarkey, William B. / Stress-related changes in proinflammatory cytokine production in wounds. In: Archives of General Psychiatry. 1999 ; Vol. 56, No. 5. pp. 450-456.
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