TY - JOUR
T1 - Stress enhances the development of tolerance to the hypothermic effect of ethanol
AU - Peris, J.
AU - Cunningham, C. L.
N1 - Copyright:
Copyright 2004 Elsevier B.V., All rights reserved.
PY - 1987
Y1 - 1987
N2 - Handling procedures used for body temperature measurement in rats, such as repeated rectal probing during restraint, raise body temperature in a manner similar to other stressors. Thus, the common use of this procedure to monitor temperature may actually obscure the results of experiments measuring the acute and chronic effects of alcohol. In the present experiment, temperature was continuously monitored with implanted biotelemetric sensors, thus eliminating the need for repeated stressful handling. Handling stress was found to interact with the effects of ethanol intoxication to augment the initial hypethermic effect of ethanol. Moreover, the rate and extent of tolerance development to ethanol-induced hypothermia was enhanced.
AB - Handling procedures used for body temperature measurement in rats, such as repeated rectal probing during restraint, raise body temperature in a manner similar to other stressors. Thus, the common use of this procedure to monitor temperature may actually obscure the results of experiments measuring the acute and chronic effects of alcohol. In the present experiment, temperature was continuously monitored with implanted biotelemetric sensors, thus eliminating the need for repeated stressful handling. Handling stress was found to interact with the effects of ethanol intoxication to augment the initial hypethermic effect of ethanol. Moreover, the rate and extent of tolerance development to ethanol-induced hypothermia was enhanced.
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M3 - Article
C2 - 3827999
AN - SCOPUS:0023149932
SN - 0883-1386
VL - 7
SP - 187
EP - 193
JO - Alcohol and drug research
JF - Alcohol and drug research
IS - 3
ER -