Streptokinase and heparin in the treatment of pulmonary embolism

A randomized comparison

C. T. Dotter, A. J. Seaman, Josef Rosch, J. M. Porter

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Treatment with streptokinase followed by heparin was compared on a randomized basis with treatment with heparin alone in patients with acute pulmonary embolism. The diagnosis and results of treatment were established by pulmonary angiography. Fifteen patients received streptokinase and 16 received heparin alone. Complications included bleeding and pyrexia in both treatment groups and anaphylaxis in a patient receiving streptokinase. There were three deaths attributed to the disease its treatment. Patients in the streptokinase group had significantly greater angiographic improvement (P=0.0125) than those in the heparin group.

Original languageEnglish (US)
Pages (from-to)42-52
Number of pages11
JournalVascular Surgery
Volume13
Issue number1
StatePublished - 1979

Fingerprint

Streptokinase
Pulmonary Embolism
Heparin
Therapeutics
Anaphylaxis
Angiography
Fever
Hemorrhage
Lung

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Dotter, C. T., Seaman, A. J., Rosch, J., & Porter, J. M. (1979). Streptokinase and heparin in the treatment of pulmonary embolism: A randomized comparison. Vascular Surgery, 13(1), 42-52.

Streptokinase and heparin in the treatment of pulmonary embolism : A randomized comparison. / Dotter, C. T.; Seaman, A. J.; Rosch, Josef; Porter, J. M.

In: Vascular Surgery, Vol. 13, No. 1, 1979, p. 42-52.

Research output: Contribution to journalArticle

Dotter, CT, Seaman, AJ, Rosch, J & Porter, JM 1979, 'Streptokinase and heparin in the treatment of pulmonary embolism: A randomized comparison', Vascular Surgery, vol. 13, no. 1, pp. 42-52.
Dotter, C. T. ; Seaman, A. J. ; Rosch, Josef ; Porter, J. M. / Streptokinase and heparin in the treatment of pulmonary embolism : A randomized comparison. In: Vascular Surgery. 1979 ; Vol. 13, No. 1. pp. 42-52.
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