Strategies to target non-T-cell HIV reservoirs

Jonah Sacha, Lishomwa C. Ndhlovu

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

PURPOSE OF REVIEW: A central question for the HIV cure field is to determine new ways to target clinically relevant, latently and actively replicating HIV-infected cells beyond resting memory CD4 T cells, particularly in anatomical areas of low drug penetrability. RECENT FINDINGS: HIV eradication strategies being positioned for targeting HIV for extinction in the CD4 T-cell compartment may also show promise in non-CD4 T-cells reservoirs. Furthermore, several exciting novel therapeutic approaches specifically focused on HIV clearance from non-CD4 T-cell populations are being developed. SUMMARY: Although reservoir validity in these non-CD4 T cells continues to remain debated, this review will highlight recent advances and make an argument as to their clinical relevancy as we progress towards an HIV cure.

Original languageEnglish (US)
JournalCurrent Opinion in HIV and AIDS
DOIs
StateAccepted/In press - Mar 25 2016

Fingerprint

HIV
T-Lymphocytes
Pharmaceutical Preparations
Population
Therapeutics

ASJC Scopus subject areas

  • Hematology
  • Oncology(nursing)
  • Immunology
  • Infectious Diseases
  • Virology
  • Oncology

Cite this

Strategies to target non-T-cell HIV reservoirs. / Sacha, Jonah; Ndhlovu, Lishomwa C.

In: Current Opinion in HIV and AIDS, 25.03.2016.

Research output: Contribution to journalArticle

@article{7b3fee203fb641a483aa1d19c2d1645d,
title = "Strategies to target non-T-cell HIV reservoirs",
abstract = "PURPOSE OF REVIEW: A central question for the HIV cure field is to determine new ways to target clinically relevant, latently and actively replicating HIV-infected cells beyond resting memory CD4 T cells, particularly in anatomical areas of low drug penetrability. RECENT FINDINGS: HIV eradication strategies being positioned for targeting HIV for extinction in the CD4 T-cell compartment may also show promise in non-CD4 T-cells reservoirs. Furthermore, several exciting novel therapeutic approaches specifically focused on HIV clearance from non-CD4 T-cell populations are being developed. SUMMARY: Although reservoir validity in these non-CD4 T cells continues to remain debated, this review will highlight recent advances and make an argument as to their clinical relevancy as we progress towards an HIV cure.",
author = "Jonah Sacha and Ndhlovu, {Lishomwa C.}",
year = "2016",
month = "3",
day = "25",
doi = "10.1097/COH.0000000000000283",
language = "English (US)",
journal = "Current Opinion in HIV and AIDS",
issn = "1746-630X",
publisher = "Lippincott Williams and Wilkins",

}

TY - JOUR

T1 - Strategies to target non-T-cell HIV reservoirs

AU - Sacha, Jonah

AU - Ndhlovu, Lishomwa C.

PY - 2016/3/25

Y1 - 2016/3/25

N2 - PURPOSE OF REVIEW: A central question for the HIV cure field is to determine new ways to target clinically relevant, latently and actively replicating HIV-infected cells beyond resting memory CD4 T cells, particularly in anatomical areas of low drug penetrability. RECENT FINDINGS: HIV eradication strategies being positioned for targeting HIV for extinction in the CD4 T-cell compartment may also show promise in non-CD4 T-cells reservoirs. Furthermore, several exciting novel therapeutic approaches specifically focused on HIV clearance from non-CD4 T-cell populations are being developed. SUMMARY: Although reservoir validity in these non-CD4 T cells continues to remain debated, this review will highlight recent advances and make an argument as to their clinical relevancy as we progress towards an HIV cure.

AB - PURPOSE OF REVIEW: A central question for the HIV cure field is to determine new ways to target clinically relevant, latently and actively replicating HIV-infected cells beyond resting memory CD4 T cells, particularly in anatomical areas of low drug penetrability. RECENT FINDINGS: HIV eradication strategies being positioned for targeting HIV for extinction in the CD4 T-cell compartment may also show promise in non-CD4 T-cells reservoirs. Furthermore, several exciting novel therapeutic approaches specifically focused on HIV clearance from non-CD4 T-cell populations are being developed. SUMMARY: Although reservoir validity in these non-CD4 T cells continues to remain debated, this review will highlight recent advances and make an argument as to their clinical relevancy as we progress towards an HIV cure.

UR - http://www.scopus.com/inward/record.url?scp=84961956354&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84961956354&partnerID=8YFLogxK

U2 - 10.1097/COH.0000000000000283

DO - 10.1097/COH.0000000000000283

M3 - Article

JO - Current Opinion in HIV and AIDS

JF - Current Opinion in HIV and AIDS

SN - 1746-630X

ER -