Abstract
Purpose of review: A central question for the HIV cure field is to determine new ways to target clinically relevant, latently and actively replicating HIV-infected cells beyond resting memory CD4+ T cells, particularly in anatomical areas of low drug penetrability. Recent findings: HIV eradication strategies being positioned for targeting HIV for extinction in the CD4+ T-cell compartment may also show promise in non-CD4+ T-cells reservoirs. Furthermore, several exciting novel therapeutic approaches specifically focused on HIV clearance from non-CD4+ T-cell populations are being developed. Summary: Although reservoir validity in these non-CD4+ T cells continues to remain debated, this review will highlight recent advances and make an argument as to their clinical relevancy as we progress towards an HIV cure.
Original language | English (US) |
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Pages (from-to) | 376-382 |
Number of pages | 7 |
Journal | Current Opinion in HIV and AIDS |
Volume | 11 |
Issue number | 4 |
DOIs | |
State | Published - Jul 1 2016 |
Keywords
- HIV
- eradication
- reservoirs
ASJC Scopus subject areas
- Immunology
- Hematology
- Oncology
- Oncology(nursing)
- Infectious Diseases
- Virology