Strategies for mapping and identifying quantitative trait loci specifying behavioral responses to alcohol

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13 Citations (Scopus)

Abstract

Most responses to alcohol in both humans and animals are heritable, and this genetic sensitivity to ethanol is determined by multiple genes. However, the number of genes, their identities, and just how they determine susceptibility to the actions of alcohol are unknown. Herein, we describe a multistage strategy for mapping quantitative trait loci (QTLs) using recombinant inbred strains and F2 mice. Precise mapping of the chromosome positions of these QTLs should increase our understanding of the genetic causes for individual differences in behavioral sensitivity to alcohol by (1) identifying genomic markers associated with sensitivity to alcohol, (2) allowing the genes specifying behavior to be cloned by position, and (3) elucidating 'candidate' genes demonstrating linkage to markers associated with behavioral responses to alcohol. Syntenic conservation between the mouse and human genomes should facilitate the eventual mapping and cloning of human homologs of these QTLs. Ultimately, cloning of these genes may allow the development of gene therapies or other therapeutic interventions for management or prevention of alcoholism and alcohol abuse.

Original languageEnglish (US)
Pages (from-to)795-801
Number of pages7
JournalAlcoholism: Clinical and Experimental Research
Volume19
Issue number4
DOIs
StatePublished - 1995

Fingerprint

Quantitative Trait Loci
Genes
Alcohols
Cloning
Alcoholism
Organism Cloning
Synteny
Inbred Strains Mice
Chromosome Mapping
Gene therapy
Human Genome
Individuality
Genetic Therapy
Chromosomes
Ethanol
Conservation
Animals

Keywords

  • Alcohol
  • Ethanol
  • Genetics
  • QTL
  • Recombinanat Inbred Strains

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

Cite this

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abstract = "Most responses to alcohol in both humans and animals are heritable, and this genetic sensitivity to ethanol is determined by multiple genes. However, the number of genes, their identities, and just how they determine susceptibility to the actions of alcohol are unknown. Herein, we describe a multistage strategy for mapping quantitative trait loci (QTLs) using recombinant inbred strains and F2 mice. Precise mapping of the chromosome positions of these QTLs should increase our understanding of the genetic causes for individual differences in behavioral sensitivity to alcohol by (1) identifying genomic markers associated with sensitivity to alcohol, (2) allowing the genes specifying behavior to be cloned by position, and (3) elucidating 'candidate' genes demonstrating linkage to markers associated with behavioral responses to alcohol. Syntenic conservation between the mouse and human genomes should facilitate the eventual mapping and cloning of human homologs of these QTLs. Ultimately, cloning of these genes may allow the development of gene therapies or other therapeutic interventions for management or prevention of alcoholism and alcohol abuse.",
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