Strategies and implications for prime-boost vaccination to generate memory CD8 T cells

Jeffrey C. Nolz, John T. Harty

Research output: Chapter in Book/Report/Conference proceedingConference contribution

25 Scopus citations

Abstract

Generating a large population of memory CD8 T cells is an appealing goal for vaccine design against a variety of human diseases. Indeed, experimental models have demonstrated that the overall number of memory CD8 T cells present at the time of infection correlates strongly with the ability to confer host protection against a range of different pathogens. Currently, the most conceivable approach to rapidly generate a large population of memory CD8 T cells is through the use of prime-boost vaccination. In addition, recent experimental findings have uncovered important principles that govern both the rate and magnitude of memory CD8 T cell formation. Thus, this has resulted in novel prime-boost vaccination strategies that could potentially be used in humans to generate protective populations of memory CD8 T cells.

Original languageEnglish (US)
Title of host publicationCrossroads Between Innate and Adaptive Immunity III
EditorsBali Pulendran, Peter Katsikis, Stephen Schoenberger
Pages69-83
Number of pages15
DOIs
StatePublished - Oct 12 2011

Publication series

NameAdvances in Experimental Medicine and Biology
Volume780
ISSN (Print)0065-2598

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Nolz, J. C., & Harty, J. T. (2011). Strategies and implications for prime-boost vaccination to generate memory CD8 T cells. In B. Pulendran, P. Katsikis, & S. Schoenberger (Eds.), Crossroads Between Innate and Adaptive Immunity III (pp. 69-83). (Advances in Experimental Medicine and Biology; Vol. 780). https://doi.org/10.1007/978-1-4419-5632-3_7