Strategies and implications for prime-boost vaccination to generate memory CD8 T cells

Jeffrey C. Nolz; John T. Harty

doi:10.1007/978-1-4419-5632-3_7

Strategies and implications for prime-boost vaccination to generate memory CD8 T cells

Jeffrey C. Nolz, John T. Harty

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

31 Scopus citations

Abstract

Generating a large population of memory CD8 T cells is an appealing goal for vaccine design against a variety of human diseases. Indeed, experimental models have demonstrated that the overall number of memory CD8 T cells present at the time of infection correlates strongly with the ability to confer host protection against a range of different pathogens. Currently, the most conceivable approach to rapidly generate a large population of memory CD8 T cells is through the use of prime-boost vaccination. In addition, recent experimental findings have uncovered important principles that govern both the rate and magnitude of memory CD8 T cell formation. Thus, this has resulted in novel prime-boost vaccination strategies that could potentially be used in humans to generate protective populations of memory CD8 T cells.

Original language	English (US)
Title of host publication	Crossroads Between Innate and Adaptive Immunity III
Editors	Bali Pulendran, Peter Katsikis, Stephen Schoenberger
Pages	69-83
Number of pages	15
DOIs	https://doi.org/10.1007/978-1-4419-5632-3_7
State	Published - 2011
Externally published	Yes

Publication series

Name	Advances in Experimental Medicine and Biology
Volume	780
ISSN (Print)	0065-2598

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1007/978-1-4419-5632-3_7

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Strategies and implications for prime-boost vaccination to generate memory CD8 T cells. / Nolz, Jeffrey C.; Harty, John T.
Crossroads Between Innate and Adaptive Immunity III. ed. / Bali Pulendran; Peter Katsikis; Stephen Schoenberger. 2011. p. 69-83 (Advances in Experimental Medicine and Biology; Vol. 780).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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Strategies and implications for prime-boost vaccination to generate memory CD8 T cells

Abstract

Publication series

ASJC Scopus subject areas

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