Stimulation of mouse lymphocytes by insoluble anti-mouse immunoglobulin

David Parker

Research output: Contribution to journalArticle

113 Citations (Scopus)

Abstract

IT is generally agreed that B-cell surface immunoglobulin (Ig) functions as the receptor for antigen, and so accounts for the specificity of the immune response by clonal selection. It is not known, however, how the combination of surface Ig with antigen stimulates the cell to proliferation and/or differentiation to secrete antibody at a high rate1. A signal could be delivered directly through the receptors, either by an allosteric transition in the receptor itself or by cross-linkage or aggregation of receptor Ig in the fluid cell membrane, analogous to antigen-induced or anti-IgE-induced histamine release from mast cells2. Alternatively, the receptor may act passively as an antigen-specific 'address' for the delivery of an antigen-associated nonspecific (that is, potentially polyclonal) signal to some other site on the cell surface3.

Original languageEnglish (US)
Pages (from-to)361-363
Number of pages3
JournalNature
Volume258
Issue number5533
DOIs
StatePublished - 1975
Externally publishedYes

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Lymphocyte Activation
Immunoglobulins
Antigens
B-Cell Antigen Receptors
Receptor Aggregation
Antigen Receptors
Histamine Release
Cell Differentiation
B-Lymphocytes
Cell Proliferation
Cell Membrane
Antibodies

ASJC Scopus subject areas

  • General

Cite this

Stimulation of mouse lymphocytes by insoluble anti-mouse immunoglobulin. / Parker, David.

In: Nature, Vol. 258, No. 5533, 1975, p. 361-363.

Research output: Contribution to journalArticle

Parker, David. / Stimulation of mouse lymphocytes by insoluble anti-mouse immunoglobulin. In: Nature. 1975 ; Vol. 258, No. 5533. pp. 361-363.
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