Stimulation of cAMP response element (CRE)-mediated transcription during contextual learning

Soren Impey, Dave M. Smith, Karl Obrietan, Rachel Donahue, Christian Wade, Daniel R. Storm

Research output: Contribution to journalArticle

423 Citations (Scopus)

Abstract

Recent studies suggest that the CREB-CRE transcriptional pathway is pivotal in the formation of some types of long-term memory. However, it has not been demonstrated that stimuli that induce learning and memory activate CRE-mediated gene expression. To address this issue, we used a mouse strain transgenic for a CRE-lac Z reporter to examine the effects of hippocampus-dependent learning on CRE-mediated gene expression in the brain. Training for contextual conditioning or pas-sive avoidance led to significant increases in CRE-dependent gene expression in areas CA1 and CA3 of the hippocampus. Auditory cue fear-conditioning, which is amygdala dependent, was associated with increased CRE-mediated gene expression in the amygdala, but not the hippocampus. These data demonstrate that learning in response to behavioral conditioning activates the CRE transcriptional pathway in specific areas of brain.

Original languageEnglish (US)
Pages (from-to)595-601
Number of pages7
JournalNature Neuroscience
Volume1
Issue number7
StatePublished - Nov 1998
Externally publishedYes

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Response Elements
Learning
Gene Expression
Hippocampus
Amygdala
Long-Term Memory
Brain
Transgenic Mice
Fear
Cues
Conditioning (Psychology)

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Impey, S., Smith, D. M., Obrietan, K., Donahue, R., Wade, C., & Storm, D. R. (1998). Stimulation of cAMP response element (CRE)-mediated transcription during contextual learning. Nature Neuroscience, 1(7), 595-601.

Stimulation of cAMP response element (CRE)-mediated transcription during contextual learning. / Impey, Soren; Smith, Dave M.; Obrietan, Karl; Donahue, Rachel; Wade, Christian; Storm, Daniel R.

In: Nature Neuroscience, Vol. 1, No. 7, 11.1998, p. 595-601.

Research output: Contribution to journalArticle

Impey, S, Smith, DM, Obrietan, K, Donahue, R, Wade, C & Storm, DR 1998, 'Stimulation of cAMP response element (CRE)-mediated transcription during contextual learning', Nature Neuroscience, vol. 1, no. 7, pp. 595-601.
Impey S, Smith DM, Obrietan K, Donahue R, Wade C, Storm DR. Stimulation of cAMP response element (CRE)-mediated transcription during contextual learning. Nature Neuroscience. 1998 Nov;1(7):595-601.
Impey, Soren ; Smith, Dave M. ; Obrietan, Karl ; Donahue, Rachel ; Wade, Christian ; Storm, Daniel R. / Stimulation of cAMP response element (CRE)-mediated transcription during contextual learning. In: Nature Neuroscience. 1998 ; Vol. 1, No. 7. pp. 595-601.
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