Stimulated exocytosis of endosomes in goldfish retinal bipolar neurons

Michael R. Coggins, Chad P. Grabner, Wolfhard Almers, David Zenisek

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

After exocytosis, synaptic vesicle components are selectively retrieved by clathrin-mediated endocytosis and then re-used in future rounds of transmitter release. Under some conditions, synaptic terminals in addition perform bulk endocytosis of large membranous sacs. Bulk endocytosis is less selective than clathrin-mediated endocytosis and probably internalizes components normally targeted to the plasma membrane. Nonetheless, this process plays a major role in some tonic ribbon-type synapses, which release neurotransmitter for prolonged periods of time. We show here, that large endosomes formed after strong and prolonged stimulation undergo stimulated exocytosis in retinal bipolar neurons. The result suggests how cells might return erroneously internalized components to the plasma membrane, and also demonstrates that synaptic vesicles are not the only neuronal organelle that stains with styryl dyes and undergoes stimulated exocytosis.

Original languageEnglish (US)
Pages (from-to)853-865
Number of pages13
JournalJournal of Physiology
Volume584
Issue number3
DOIs
StatePublished - Nov 1 2007

ASJC Scopus subject areas

  • Physiology

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