Stimulant and depressant properties of sedative-hypnotics in mice selectively bred for differential sensitivity to ethanol

Bruce C. Dudek, Michael E. Abbott, Tamara J. Phillips

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

A genetic analysis of sedative-hypnotic response in selectively bred Long-Sleep (LS) and Short-Sleep (SS) mice showed LS mice to be more depressed by acetaldehyde, ethanol (ETOH), and t-butanol, but less sensitive to pentobarbital. Intermediate inheritance was shown by the two reciprocal F1 hybrids for the alcohols, but dominance to the LS genotype occurred for the aldehyde and the barbiturate. At severa subhypnotic doses of ETOH in two experiments, LS mice showed less locomotor stimulation and greater disruption of coordination than the SS mice. The two reciprocal F1 hybrids did not differ form one another and had dose-response curves intermediated to the two parental lines. Study of the effects of t-butanol on locomotor activity revealed a pattern of line differences similar to that for ETOH. The genetic selection for LS and SS mice appears to have differentiated loci that pleiotropically influence a variety of behavioral responses to alcohols.

Original languageEnglish (US)
Pages (from-to)46-51
Number of pages6
JournalPsychopharmacology
Volume82
Issue number1-2
DOIs
StatePublished - Dec 1983

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Keywords

  • Acetaldehyde
  • Alcohols
  • Coordination
  • Locomotor activity
  • Pentobarbital
  • Pharmacogenetics

ASJC Scopus subject areas

  • Pharmacology

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