Stillbirth classification-developing an international consensus for research

Executive summary of a national institute of child health and human development workshop

Uma M. Reddy, Robert Goldenberg, Robert Silver, Gordon C S Smith, Richard M. Pauli, Ronald J. Wapner, Jason Gardosi, Halit Pinar, Marjorie Grafe, Michael Kupferminc, Ingela Hulthén Varli, Jan Jaap H M Erwich, Ruth C. Fretts, Marian Willinger

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

Stillbirth is a major obstetric complication, with 3.2 million stillbirths worldwide and 26,000 stillbirths in the United States every year. The Eunice Kennedy Shriver National Institute of Child Health and Human Development held a workshop from October 22-24, 2007, to review the pathophysiology of conditions underlying stillbirth to define causes of death. The optimal classification system would identify the pathophysiologic entity initiating the chain of events that irreversibly led to death. Because the integrity of the classification is based on available pathologic, clinical, and diagnostic data, experts emphasized that a complete stillbirth workup should be performed. Experts developed evidence-based characteristics of maternal, fetal, and placental conditions to attribute a condition as a cause of stillbirth. These conditions include infection, maternal medical conditions, antiphospholipid syndrome, heritable thrombophilias, red cell alloimmunization, platelet alloimmunization, congenital malformations, chromosomal abnormalities including confined placental mosaicism, fetomaternal hemorrhage, placental and umbilical cord abnormalities including vasa previa and placental abruption, complications of multifetal gestation, and uterine complications. In all cases, owing to lack of sufficient knowledge about disease states and normal development, there will be a degree of uncertainty regarding whether a specific condition was indeed the cause of death.

Original languageEnglish (US)
Pages (from-to)901-914
Number of pages14
JournalObstetrics and Gynecology
Volume114
Issue number4
DOIs
StatePublished - Oct 2009

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National Institute of Child Health and Human Development (U.S.)
Stillbirth
Education
Research
Cause of Death
Vasa Previa
Fetomaternal Transfusion
Mothers
Abruptio Placentae
Mosaicism
Antiphospholipid Syndrome
Umbilical Cord
Chromosome Aberrations
Obstetrics
Uncertainty
Blood Platelets
Pregnancy
Infection

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Stillbirth classification-developing an international consensus for research : Executive summary of a national institute of child health and human development workshop. / Reddy, Uma M.; Goldenberg, Robert; Silver, Robert; Smith, Gordon C S; Pauli, Richard M.; Wapner, Ronald J.; Gardosi, Jason; Pinar, Halit; Grafe, Marjorie; Kupferminc, Michael; Hulthén Varli, Ingela; Erwich, Jan Jaap H M; Fretts, Ruth C.; Willinger, Marian.

In: Obstetrics and Gynecology, Vol. 114, No. 4, 10.2009, p. 901-914.

Research output: Contribution to journalArticle

Reddy, UM, Goldenberg, R, Silver, R, Smith, GCS, Pauli, RM, Wapner, RJ, Gardosi, J, Pinar, H, Grafe, M, Kupferminc, M, Hulthén Varli, I, Erwich, JJHM, Fretts, RC & Willinger, M 2009, 'Stillbirth classification-developing an international consensus for research: Executive summary of a national institute of child health and human development workshop', Obstetrics and Gynecology, vol. 114, no. 4, pp. 901-914. https://doi.org/10.1097/AOG.0b013e3181b8f6e4
Reddy, Uma M. ; Goldenberg, Robert ; Silver, Robert ; Smith, Gordon C S ; Pauli, Richard M. ; Wapner, Ronald J. ; Gardosi, Jason ; Pinar, Halit ; Grafe, Marjorie ; Kupferminc, Michael ; Hulthén Varli, Ingela ; Erwich, Jan Jaap H M ; Fretts, Ruth C. ; Willinger, Marian. / Stillbirth classification-developing an international consensus for research : Executive summary of a national institute of child health and human development workshop. In: Obstetrics and Gynecology. 2009 ; Vol. 114, No. 4. pp. 901-914.
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