Background: Systemic acetazolamide treatment has been reported in association with Stevens-Johnson syndrome (SJS). This is the first report of this syndrome associated with methazolamide treatment. The association is reported in two Japanese-American women. Method and Results: Two patients with SJS, which developed during treatment with methazolamide, are described. Other potential associations are discussed. Conclusions: Systemically administered carbonic anhydrase inhibitors, including both acetazolamide and methazolamide, can be associated with SJS.
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