Steroids for acute respiratory distress syndrome?

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations

Abstract

The development and severity of acute respiratory distress syndrome (ARDS) are closely related to dysregulated inflammation, and the duration of ARDS and eventual outcomes are related to persistent inflammation and abnormal fibroproliferation. Corticosteroids are potent modulators of inflammation and inhibitors of fibrosis that have been used since the first description of ARDS in attempts to improve outcomes. There is no evidence that corticosteroids prevent the development of ARDS among patients at risk. High-dose and short-course treatment with steroids does not improve the outcomes of patients with ARDS. Additional studies are needed to recommend treatment with steroids for ARDS.

Original languageEnglish (US)
Pages (from-to)781-795
Number of pages15
JournalClinics in Chest Medicine
Volume35
Issue number4
DOIs
StatePublished - Dec 1 2014
Externally publishedYes

Keywords

  • ARDS
  • Corticosteroids
  • Outcomes
  • Prevention
  • Treatment

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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